지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background : Peripheral nerve injuries are commonly encountered clinical problems and often result in severe functional deficit. Bee venom acupuncture has traditionally been used to treat several inflammatory diseases and chronic pain conditions.
Objectives : The aims of this study were to compare the effects of bee venom (general bee venom, BV) and sweet bee venom (allergen-removed bee venom, SBV) acupuncture on the recovery rate of locomotor function, the expression of brain-derived neurotrophic factor (BDNF) in the sciatic nerve, and the expression of c-Fos in the brain following sciatic crushed nerve injury in rats, and to evaluate differences due to administration areas.
Method : Walking track analysis, Western blot for BDNF and tyrosine receptor kinase B (TrkB), and immunohistochemistry for c-Fos were performed. In this study, comparative analyses of the effects of BV and SBV acupuncture in relation to administration sites, contralateral side or ipsilateral side, were conducted.
Results : In the present result, sciatic function index (SFI) in walking track analysis significantly decreased following sciatic crushed nerve injury. The expressions of BDNF and TrkB in the sciatic nerve increased after induction of sciatic crushed nerve injury. C-Fos expression in the ventrolateral periaqueductal gray (vlPAG) and paraventricular nucleus (PVN) also increased. BV and SBV acupuncture treatment improved the SFI in walking track analysis. Treatment with SBV at 1mg/kg showed more potent enhancing effect on SFI compared to BV. Treatment with 1mg/kg BV or 1mg/kg SBV acupuncture suppressed the BDNF and TrkB expression in the sciatic nerve. BV and SBV acupuncture treatment also suppressed c-Fos expression in the PVN and vlPAG regions. Treatment with SBV at 1mg/kg showed more potent suppressing effect on c-Fos expression compared to BV when injected into the contralateral side of the injured nerve. Generally we could not find significant difference in the effects between contralateral side and ipsilateral side of the injured nerve.
Conclusion : We have shown that BV and SBV acupuncture treatment can be used as the effective therapeutic modality to ameliorate the symptoms of sciatic crushed nerve injury.
Objectives : The aims of this study were to compare the effects of bee venom (general bee venom, BV) and sweet bee venom (allergen-removed bee venom, SBV) acupuncture on the recovery rate of locomotor function, the expression of brain-derived neurotrophic factor (BDNF) in the sciatic nerve, and the expression of c-Fos in the brain following sciatic crushed nerve injury in rats, and to evaluate differences due to administration areas.
Method : Walking track analysis, Western blot for BDNF and tyrosine receptor kinase B (TrkB), and immunohistochemistry for c-Fos were performed. In this study, comparative analyses of the effects of BV and SBV acupuncture in relation to administration sites, contralateral side or ipsilateral side, were conducted.
Results : In the present result, sciatic function index (SFI) in walking track analysis significantly decreased following sciatic crushed nerve injury. The expressions of BDNF and TrkB in the sciatic nerve increased after induction of sciatic crushed nerve injury. C-Fos expression in the ventrolateral periaqueductal gray (vlPAG) and paraventricular nucleus (PVN) also increased. BV and SBV acupuncture treatment improved the SFI in walking track analysis. Treatment with SBV at 1mg/kg showed more potent enhancing effect on SFI compared to BV. Treatment with 1mg/kg BV or 1mg/kg SBV acupuncture suppressed the BDNF and TrkB expression in the sciatic nerve. BV and SBV acupuncture treatment also suppressed c-Fos expression in the PVN and vlPAG regions. Treatment with SBV at 1mg/kg showed more potent suppressing effect on c-Fos expression compared to BV when injected into the contralateral side of the injured nerve. Generally we could not find significant difference in the effects between contralateral side and ipsilateral side of the injured nerve.
Conclusion : We have shown that BV and SBV acupuncture treatment can be used as the effective therapeutic modality to ameliorate the symptoms of sciatic crushed nerve injury.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusion
Acknowledgement
References
참고문헌 (75)
참고문헌 신청
1. [학술지(정기간행물)] - Bennett GJ / 1998 / A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man / Pain 33 : 87 ~ 107
2. [학술지(정기간행물)] - Raso VV / 2005 / Can therapeutic ultrasound influence the regeneration of peripheral nerves? / J Neurosci Methods. 142 : 185 ~ 192
3. [학위논문] - Kim DF / 2007 / Effects of Acupuncture stimulation at Huatuo Jiaji (EX B2) points on axonal regeneration of injured sciatic nerve in rats. Thesis for the degree of doctor of philosophy in Oriental medicine / Dongguk university
4. [학술지(정기간행물)] - 안혜림 / 2009 / 좌골신경 압좌 손상 후 전침 및 녹용 약침의 통증 감소와 신경 재생에 관한 실험적 연구 / 한방재활의학과학회지 19 (1) : 39 ~ 55
5. [학술지(정기간행물)] - 양미성 / 2008 / 흰쥐 좌골신경 압좌 손상 후 오약순기산 및 전침이 신경손상의 회복에 미치는 영향 / 한방재활의학과학회지 18 (4) : 25 ~ 37
2. [학술지(정기간행물)] - Raso VV / 2005 / Can therapeutic ultrasound influence the regeneration of peripheral nerves? / J Neurosci Methods. 142 : 185 ~ 192
3. [학위논문] - Kim DF / 2007 / Effects of Acupuncture stimulation at Huatuo Jiaji (EX B2) points on axonal regeneration of injured sciatic nerve in rats. Thesis for the degree of doctor of philosophy in Oriental medicine / Dongguk university
4. [학술지(정기간행물)] - 안혜림 / 2009 / 좌골신경 압좌 손상 후 전침 및 녹용 약침의 통증 감소와 신경 재생에 관한 실험적 연구 / 한방재활의학과학회지 19 (1) : 39 ~ 55
5. [학술지(정기간행물)] - 양미성 / 2008 / 흰쥐 좌골신경 압좌 손상 후 오약순기산 및 전침이 신경손상의 회복에 미치는 영향 / 한방재활의학과학회지 18 (4) : 25 ~ 37
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UCI(KEPA) : I410-ECN-0101-2014-519-000262478