지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objective : To derive information on the efficacy of Sam-chul-kun-bi-tang (SKT), by evaluating its anti-inflammatory effect. SKT is a widely-used herbal formula in traditional Korean medicine. In many studies, plant-derived anti-inflammatory efficacies have been investigated for their potential inhibitory effects on lipopolysaccharide (LPS)-stimulated macrophages. This study was performed to examine the anti-inflammatory effects of SKT extract on LPS-stimulated RAW 264.7 cells.
Methods : The production of nitric oxide (NO), prostaglandin (PG)E2, tumor necrosis factor (TNF)-α and interleukin (IL)-6 were examined in a macrophage cell line, RAW 264.7 cells, in the presence of SKT. RAW 264.7 cells were incubated with LPS 1 μg/mL and SKT for 18 hrs. The anti-inflammatory activity of SKT was investigated by carrageenan-induced paw edema in rats. The paw volume was measured at 2 and 4 hrs following carrageenan-induced paw edema in rats.
Results : SKT showed inhibitory effect on PGE2, TNF-α and IL-6 in LPS-stimulated RAW 264.7 cells. But SKT was not inhibitory effect on NO by LPS-stimulated RAW 264.7 cells. Administration of SKT (1 g/kg) also showed a reduction in carrageenan-induced paw edema on rats.
Conclusion : These results suggest that SKT has anti-inflammatory activities in both in vitro and in vivo models.
Methods : The production of nitric oxide (NO), prostaglandin (PG)E2, tumor necrosis factor (TNF)-α and interleukin (IL)-6 were examined in a macrophage cell line, RAW 264.7 cells, in the presence of SKT. RAW 264.7 cells were incubated with LPS 1 μg/mL and SKT for 18 hrs. The anti-inflammatory activity of SKT was investigated by carrageenan-induced paw edema in rats. The paw volume was measured at 2 and 4 hrs following carrageenan-induced paw edema in rats.
Results : SKT showed inhibitory effect on PGE2, TNF-α and IL-6 in LPS-stimulated RAW 264.7 cells. But SKT was not inhibitory effect on NO by LPS-stimulated RAW 264.7 cells. Administration of SKT (1 g/kg) also showed a reduction in carrageenan-induced paw edema on rats.
Conclusion : These results suggest that SKT has anti-inflammatory activities in both in vitro and in vivo models.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusion
Acknowledgments
Reference
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Lee SY / 1998 / Effects of Samchulkunbitang on the immunosuppression induced by methotrexate in rats / Journal of Korean oriental pediatrics 12 : 257 ~ 276
2. [학술지(정기간행물)] - Kim SW / 1988 / Effect of Samchulkunbitang on the gastric secretion and intestinal transport in the rat / Journal of Korean oriental pediatrics 3 : 84 ~ 90
3. [학술지(정기간행물)] - Radad K / 2006 / Use of ginseng in medicine with emphasis on neurodegenerative disorders / J Pharmacol Sci 100 : 175 ~ 186
4. [학술지(정기간행물)] - Park JS / 2009 / Anti-inflammatory mechanism of ginseng saponins in activated microglia / J Neuroimmunol 209 : 40 ~ 49
5. [학술지(정기간행물)] - Chun HJ / 2001 / Inhibitory effects of ethanol extract of Atractylodis rhizome alba on melanin biosynthesis / The Pharmaceutical society of Korea 45 : 269 ~ 275
2. [학술지(정기간행물)] - Kim SW / 1988 / Effect of Samchulkunbitang on the gastric secretion and intestinal transport in the rat / Journal of Korean oriental pediatrics 3 : 84 ~ 90
3. [학술지(정기간행물)] - Radad K / 2006 / Use of ginseng in medicine with emphasis on neurodegenerative disorders / J Pharmacol Sci 100 : 175 ~ 186
4. [학술지(정기간행물)] - Park JS / 2009 / Anti-inflammatory mechanism of ginseng saponins in activated microglia / J Neuroimmunol 209 : 40 ~ 49
5. [학술지(정기간행물)] - Chun HJ / 2001 / Inhibitory effects of ethanol extract of Atractylodis rhizome alba on melanin biosynthesis / The Pharmaceutical society of Korea 45 : 269 ~ 275
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UCI(KEPA) : I410-ECN-0101-2014-519-000262443