지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 1 - 11 (11page)
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Objectives : The purpose of this study was to investigate the differences of chemical composition or biological activities between decoction and commercial herbal medicines of Samchulkunbi-tang (Shenzhujianpi-tang, SKT). Methods : The extracts of SKT from decoction (SKT1) and two different commercial extractive granules (SKT2 and SKT3) were prepared. The index components of SKTs were analyzed with HPLC. The antioxidant activities of SKTs were studied by measuring free radical scavenging activities on ABTS and DPPH. The anti-inflammatory effects were determined by measuring NO, $PGE_2$ and IL-6 in LPS-stimulated RAW 264.7 cells. Results : The contents of 7 components were 1.40-6.08 mg/g in SKT1, not detected-4.75 mg/g in SKT2, 0.03-1.46 mg/g in SKT3. The scavenging activities on ABTS and DPPH of herbal formulas were increased in dose-dependent manner (SKT1>SKT2>SKT3). SKT1 significantly inhibited $PGE_2$ and IL-6 production and SKT3 slightly inhibited $PGE_2$ production in LPS-stimulated RAW264.7 cells. SKT2 showed no inhibitory effects on production of inflammatory mediators such as $PGE_2$ and IL-6. Conclusions : These results demonstrate that the decoction of SKT has more strong anti-oxidant and anti-inflammatory effects than that of commercial herbal medicines consistent with the contents of index components.
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참고문헌 (31)
참고문헌 신청
허준 / 2007 / 원본 동의보감. 신증판 / 남산당 :431
윤용갑 / 2004 / 동의방제와 처방해설. 개정판 / 의성당 :158
Kim T / 1997 / An experimental study on the effect of Samchulgunbitang affecting gastro-intestin and central nervous system / J Korean Oriental Inten Med 18(1):1~14
Kim SW / 1998 / Effect of Samchulkunbitang on gastric secretion and intestinal transport in the rat / Korean J Orient Med Pathol 3:84~90
Lee S / 1998 / Effects of Samchulkunbitang on the immunosuppression induced by methotrexate in rats / J Korean Oriental Pediatr 12(1):257~276
윤용갑 / 2004 / 동의방제와 처방해설. 개정판 / 의성당 :158
Kim T / 1997 / An experimental study on the effect of Samchulgunbitang affecting gastro-intestin and central nervous system / J Korean Oriental Inten Med 18(1):1~14
Kim SW / 1998 / Effect of Samchulkunbitang on gastric secretion and intestinal transport in the rat / Korean J Orient Med Pathol 3:84~90
Lee S / 1998 / Effects of Samchulkunbitang on the immunosuppression induced by methotrexate in rats / J Korean Oriental Pediatr 12(1):257~276
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