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초록· 키워드
오류제보하기
Objectives: This study was to investigate the anti-oxidation and anti-cancer activity of Chaga mushroom extract. Extraction condition optimization and beta-glucan analysis and anti-cancer activity tests were also done.
Methods: Optimum extraction conditions for Chaga mushroom extract were at a temperature of 90℃ and 2hrs with 10 times of water. Extraction yield and economics were best under these conditions.
Results: Anti-oxidation activity was the highest with the fraction of 100,000 MWCO and IC50 value was 13㎍/㎖, and this value was comparable to that of vitamin E, alpha-tocopherol. Among the fractions from various organic solvents, ethyl acetate fraction showed the highest anti-oxidation activity with IC50 value of 7㎍/㎖. For anti-cancer activity, chloroform fraction showed little anti-cancer activity and ethyl acetate fraction showed the best anti-cancer activity with IC50 1.5㎍/㎖ for stomach cancer cells. Anti-cancer activities for different molecular weight fractions were the best in the fraction of molecular weight less than 100,000Da, and IC50 values for stomach cancer cells and liver cancer cells were 1.7 and 1.4㎍/㎖, respectively.
Conclusions: From these results, we can conclude that the extract of Chaga mushroom could be a good source for functional food and natural anti-cancer medicine .
Methods: Optimum extraction conditions for Chaga mushroom extract were at a temperature of 90℃ and 2hrs with 10 times of water. Extraction yield and economics were best under these conditions.
Results: Anti-oxidation activity was the highest with the fraction of 100,000 MWCO and IC50 value was 13㎍/㎖, and this value was comparable to that of vitamin E, alpha-tocopherol. Among the fractions from various organic solvents, ethyl acetate fraction showed the highest anti-oxidation activity with IC50 value of 7㎍/㎖. For anti-cancer activity, chloroform fraction showed little anti-cancer activity and ethyl acetate fraction showed the best anti-cancer activity with IC50 1.5㎍/㎖ for stomach cancer cells. Anti-cancer activities for different molecular weight fractions were the best in the fraction of molecular weight less than 100,000Da, and IC50 values for stomach cancer cells and liver cancer cells were 1.7 and 1.4㎍/㎖, respectively.
Conclusions: From these results, we can conclude that the extract of Chaga mushroom could be a good source for functional food and natural anti-cancer medicine .
목차
서론
실험재료 및 방법
결과 및 고찰
결론
참고문헌
참고문헌 (27)
참고문헌 신청
1. [보고서] - 심재성 / 2003 / 암, 에이즈 및 당뇨를 치료하는 차가버섯의 실체와 응용 : 10 ~ 35
2. [학술지(정기간행물)] - Shivrina AN / 1967 / Chemical characteristics of compounds extracted from Inonotus obliquus / Chem. Abstr 66 : 17271 ~ 17279
3. [학술지(정기간행물)] - Kier L / 1961 / Triterpenes of Poria obliqua / J. Pharm. Sci 50 : 471 ~ 474
4. [학술지(정기간행물)] - Ludwiezak RS / 1975 / Forschungen uber die cgemischen bestandteil de Inonotus obliquus. IV / Ergosterol Rocz. Chem 34 : 1701 ~ 1705
5. [학술지(정기간행물)] - Kahlos K / 1983 / Identification of some lanostane type triterpenes from Inonotus obliquus / Acta. Pharm. Fenn 92 : 220 ~ 224
2. [학술지(정기간행물)] - Shivrina AN / 1967 / Chemical characteristics of compounds extracted from Inonotus obliquus / Chem. Abstr 66 : 17271 ~ 17279
3. [학술지(정기간행물)] - Kier L / 1961 / Triterpenes of Poria obliqua / J. Pharm. Sci 50 : 471 ~ 474
4. [학술지(정기간행물)] - Ludwiezak RS / 1975 / Forschungen uber die cgemischen bestandteil de Inonotus obliquus. IV / Ergosterol Rocz. Chem 34 : 1701 ~ 1705
5. [학술지(정기간행물)] - Kahlos K / 1983 / Identification of some lanostane type triterpenes from Inonotus obliquus / Acta. Pharm. Fenn 92 : 220 ~ 224
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UCI(KEPA) : I410-ECN-0101-2014-519-000262110