지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objective : Yikgeebohyul-tang (Yiqib?xue-t?ng) is one of the representative prescriptions for invigoration of vitality and nourishing of the blood. This study was carried out to investigate the effects of Yikgeebohyul-tang (Yiqib?xue-t?ng) on hair regrowth and cytokine changes in a shaving model of C57BL6 mice.
Method : Five-week-old mice were acclimated for 1 week at a temperature between 21-23℃E, 40-60% relative humidity, and 12h of a light/dark cycle before beginning of the experiment. There were two groups including normal saline (control) and a positive control of oral intake of Yikgeebohyul-tang (Yiqib?xue-t?ng) extract (sample) in 18 female mice. The test compounds were topically treated once a day over 14 days. The hair regrowth was photographically and histologically determined during the experimental period of 14 days. Revelation of TGF-β1 and EGF were also determined using immunohistochemistry. In addition to that, IFN-γ, IL-4 and IL-10 were determined in serum.
Results : Hair regrowth in the sample group was promoted earlier and faster than the control group, as shown by concentrations of hairs and thick-hair ratio in the sample group. TGF-β1 was not revealed in either control orsample group. EGF was strongly positive in out root sheath of some thick hair of the sample group. Serum IFN-γ was significantly decreased in the sample group compared with the control group at 7 experimental days. However, it was not significantly decreased at 14 experimental days. Serum IL-4 was significantly increased in the sample group compared with the control group at 7 experimental days. However, it was not significantly decreased at 14 experimental days. Serum IL-10 was decreased in the sample group compared with the control group, but with no real statistical significance.
Conclusion : These results suggest that Yikgeebohyul-tang (Yiqib?xue-t?ng) has hair growth promoting activity and it can be used for treatment of alopecia. Also, these effects relate to EGF revelation of hair roots, a decrease in serum IFN-γ, and an increase of serum IL-4.
Method : Five-week-old mice were acclimated for 1 week at a temperature between 21-23℃E, 40-60% relative humidity, and 12h of a light/dark cycle before beginning of the experiment. There were two groups including normal saline (control) and a positive control of oral intake of Yikgeebohyul-tang (Yiqib?xue-t?ng) extract (sample) in 18 female mice. The test compounds were topically treated once a day over 14 days. The hair regrowth was photographically and histologically determined during the experimental period of 14 days. Revelation of TGF-β1 and EGF were also determined using immunohistochemistry. In addition to that, IFN-γ, IL-4 and IL-10 were determined in serum.
Results : Hair regrowth in the sample group was promoted earlier and faster than the control group, as shown by concentrations of hairs and thick-hair ratio in the sample group. TGF-β1 was not revealed in either control orsample group. EGF was strongly positive in out root sheath of some thick hair of the sample group. Serum IFN-γ was significantly decreased in the sample group compared with the control group at 7 experimental days. However, it was not significantly decreased at 14 experimental days. Serum IL-4 was significantly increased in the sample group compared with the control group at 7 experimental days. However, it was not significantly decreased at 14 experimental days. Serum IL-10 was decreased in the sample group compared with the control group, but with no real statistical significance.
Conclusion : These results suggest that Yikgeebohyul-tang (Yiqib?xue-t?ng) has hair growth promoting activity and it can be used for treatment of alopecia. Also, these effects relate to EGF revelation of hair roots, a decrease in serum IFN-γ, and an increase of serum IL-4.
목차
서론
실험
성적
고찰
결론
참고문헌
참고문헌 (59)
참고문헌 신청
1. [학술지(정기간행물)] - Otomo S / 1997 / new hair growth drugs and their nonclinical evaluation methods / Hyangjanghwoiji 21 : 228 ~
2. [학술지(정기간행물)] - Kagoura M / 1997 / Animal models for the study of alopecia / Hyangjanghwoiji 21 : 207 ~
3. [단행본] - Chao YF / 1983 / Zhubingyuanhoulun / People's Medical Publishing House : 761 ~ 767
4. [학술지(정기간행물)] - Lim SBN / 1999 / The Oriental and Western Medical Study of Alopecia / The Journal of Jeahan Oruental Medical Academy 4 (1) : 699 ~ 710
5. [학술지(정기간행물)] - Meng X / 1998 / Keratinocyte gene therapy for systemic diseases. Circulating interleukin-10 released from gene-transferred keratinocytes inhibits contact hypersensitivity at distant areas of the skin / J Clin Invest 101 (6) : 1462 ~ 1467
2. [학술지(정기간행물)] - Kagoura M / 1997 / Animal models for the study of alopecia / Hyangjanghwoiji 21 : 207 ~
3. [단행본] - Chao YF / 1983 / Zhubingyuanhoulun / People's Medical Publishing House : 761 ~ 767
4. [학술지(정기간행물)] - Lim SBN / 1999 / The Oriental and Western Medical Study of Alopecia / The Journal of Jeahan Oruental Medical Academy 4 (1) : 699 ~ 710
5. [학술지(정기간행물)] - Meng X / 1998 / Keratinocyte gene therapy for systemic diseases. Circulating interleukin-10 released from gene-transferred keratinocytes inhibits contact hypersensitivity at distant areas of the skin / J Clin Invest 101 (6) : 1462 ~ 1467
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
한약재 함유 헤어토닉 및 식품이 C57BL/6 마우스의 탈모 모델에서 모발성장에 미치는 영향
대한본초학회지(본초분과학회지)
2011 .01
-
延年益壽固本丹의 育毛效能에 대한 면역조직화학적 연구
대한한의학회지
2010 .03
-
C57BL6 마우스에서 복합생약제인 황금궁의 육모 효과
약학회지
2005 .01
-
黃芪 추출물의 외용 도포가 자발성 원형탈모 생쥐에 미치는 영향
대한한의학회지
2018 .03
-
Tendency of hair regrowth through cutaneous application of quercetin and soybean in the C57BL/6N mouse model
한국실험동물학회 학술발표대회 논문집
2018 .07
-
애엽을 포함하는 해애탕의 에탄올 추출물이 제모된 C57BL/6 마우스의 발모에 미치는 영향
대한본초학회지(본초분과학회지)
2015 .01
-
삼황사심탕의 항산화능 및 C57BL/6 마우스 모델에서의 발모 촉진효과
동의생리병리학회지
2014 .04
-
Topical Products for Human Hair Regeneration: A Comparative Study on an Animal Model
Annals of Dermatology
2016 .01
-
해조류 추출물의 발모효과에 관한 C57BL/6의 쥐 실험연구
Archives of craniofacial surgery : ACFS
2013 .01
-
C57BL6 생쥐에서 NDM 헤어토닉의 모발성장 촉진 효과
약학회지
2004 .01
-
Hair Growth-Promoting Effects of Lavender Oil in C57BL/6 Mice
Toxicological Research
2016 .04
-
Methods for Assessing Efficacy of Hair Re-growth in Telogen Mice
한국실험동물학회 학술발표대회 논문집
2016 .08
-
삼황사심탕의 항산화능 및 C57BL/6 마우스 모델에서의 발모 촉진효과
동의생리병리학회지
2014 .01
-
Hair Damage에 관한 연구
대한화장품학회지
1974 .01
-
Body Hair Scores and Total Hair Diameters in Healthy Women in Kirikkale Region, of Turkey
Yonsei Medical Journal
2004 .01
-
The Pattern of Hair Dyeing in Koreans with Gray Hair
Annals of Dermatology
2013 .01
-
Effects of Herbal Extracts on Hair Growth in an Animal Model of C3H/HeJ Mice
Laboratory Animal Research
2009 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-519-000281013