지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: The aim of this study was to elucidate the antioxidant effect of solvent fractions of Angelica gigas root.
Methods: The ethanol extract of Angelica gigas root was suspended in water and then partitioned with dichloromethane (MC Fr.), ethyl acetate (EA Fr.) and butanol (BuOH Fr.), sequentially. The antioxidant activities of solvent fractions of Angelica gigas root were evaluated for radical scavenging activity against stable free radicals(2,2-diphenyl-1-picrylhydrazyl) DPPH, hydrogen peroxide and superoxide anion radicals. In addition the antioxidant activities of solvent fractions of Angelica gigas root against peroxyl radicals, hydroxyl radicals and peroxynitrites were determined by the total oxy-radical scavenging capacity (TOSC) assay.
Results: Among the solvent fractions of MC Fr., EA Fr., and BuOH Fr., BuOH Fr. was found to have stronger antioxidant activity with IC50 values of 59.72, 14.36, 30.96 and 44.75 ㎍/㎖ on the DPPH radical, nitrite, superoxide anion and hydrogen peroxide, respectively, than BHA used as a positive control. Moreover, specific TOSC values(564.8, 276.4 and 405.5 TOSC/mM) of BuOH fr. against peroxyl radicals, hydroxyl radical and peroxynitrite were 4 times higher than GSH (136.5, 67.4 102.6 TOSC/mM) used as a positive control.
Conclusions: These results suggest that the BuOH fr. of Angelica gigas root has a high antioxidant activity and can be useful to develop functional food against oxidative stress conditions.
Methods: The ethanol extract of Angelica gigas root was suspended in water and then partitioned with dichloromethane (MC Fr.), ethyl acetate (EA Fr.) and butanol (BuOH Fr.), sequentially. The antioxidant activities of solvent fractions of Angelica gigas root were evaluated for radical scavenging activity against stable free radicals(2,2-diphenyl-1-picrylhydrazyl) DPPH, hydrogen peroxide and superoxide anion radicals. In addition the antioxidant activities of solvent fractions of Angelica gigas root against peroxyl radicals, hydroxyl radicals and peroxynitrites were determined by the total oxy-radical scavenging capacity (TOSC) assay.
Results: Among the solvent fractions of MC Fr., EA Fr., and BuOH Fr., BuOH Fr. was found to have stronger antioxidant activity with IC50 values of 59.72, 14.36, 30.96 and 44.75 ㎍/㎖ on the DPPH radical, nitrite, superoxide anion and hydrogen peroxide, respectively, than BHA used as a positive control. Moreover, specific TOSC values(564.8, 276.4 and 405.5 TOSC/mM) of BuOH fr. against peroxyl radicals, hydroxyl radical and peroxynitrite were 4 times higher than GSH (136.5, 67.4 102.6 TOSC/mM) used as a positive control.
Conclusions: These results suggest that the BuOH fr. of Angelica gigas root has a high antioxidant activity and can be useful to develop functional food against oxidative stress conditions.
목차
서론
실험재료 및 방법
통계처리
실험결과 및 고찰
결론
참고문헌
참고문헌 (28)
참고문헌 신청
1. [단행본] - 國家藥典委員會 / 2010 / 中華人民共和國藥典一部 / 中國醫藥科技出版社 : 124 ~
2. [단행본] - 日本藥局方解說書編集委員會 / 2005 / 日本藥局方解說書 15改定 / 廣川書店 : 1321 ~
3. [기타자료] - / 2010 / 식품의약품안전청 고시 제 2010-10호, 의약품각조 2부 : 916 ~
4. [학술지(정기간행물)] - YoungGooKang / 2003 / 당귀(Angelica gigas) 중 Decursin 및 Decursinol Angelate 추출 방법과 HPLC 분석 / 생약학회지 34 (3) : 201 ~ 205
5. [학술지(정기간행물)] - Chi HJ / 1970 / Studies on the components of Umbelliferae Plants in Korea / Kor. J. Pharmacogn 1 : 25 ~ 32
2. [단행본] - 日本藥局方解說書編集委員會 / 2005 / 日本藥局方解說書 15改定 / 廣川書店 : 1321 ~
3. [기타자료] - / 2010 / 식품의약품안전청 고시 제 2010-10호, 의약품각조 2부 : 916 ~
4. [학술지(정기간행물)] - YoungGooKang / 2003 / 당귀(Angelica gigas) 중 Decursin 및 Decursinol Angelate 추출 방법과 HPLC 분석 / 생약학회지 34 (3) : 201 ~ 205
5. [학술지(정기간행물)] - Chi HJ / 1970 / Studies on the components of Umbelliferae Plants in Korea / Kor. J. Pharmacogn 1 : 25 ~ 32
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UCI(KEPA) : I410-ECN-0101-2014-519-000285102