지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: The safety of herbal products is an important issue in Korea. It is more complicated because of the concomitant use of conventional western drugs and herbal medicine, including prescribed medicine, folk herbs and food supplements. Although both western and traditional Korean medical doctors have studied on the safety of HMP, their results did not show relevant or consistent conclusions because of the poor quality of studies, including bias.
Objectives: The aim of this study was to review the studies in Korea related to drug induced liver injury (DILI) systematically. We tried to estimate the proportion of causative materials of DILI and evaluate the clinical difference of DILIs from different materials.
Methods: Systematic searches were performed on MedRIC and MEDLIS in Korea. The extraction of data as well as selective screening of the studies was carried out independently by two of the authors. There were no restrictions on the types of publication, including grey literature.
Results: Twenty-one articles were included. Of them only 7 adapted prospective design and only 6 were published in peer-reviewed journals. The proportion of conventional drugs associated with hepatotoxic injuries in all DILI ranged from 15.8% to 83.3% and that of herbal medicine was from 28.9% to 44.7%. However, the criteria for herbal medicine were not clearly defined and concomitant medications were not fully investigated in most studies. There were limited objective data in the clinical differences of liver injuries from different materials and their results were conflicting.
Conclusions: The causality assessments regarding DILI of herbal medicine were not performed properly and causative materials were misclassified in most of the studies published in Korea. These make the safety issue still ambiguous because of the limitations and lack of objectivity of the studies. More rigorous studies are required for clearly addressing these conflicting issues with cooperative investigation between traditional Korean and western medicine.
Objectives: The aim of this study was to review the studies in Korea related to drug induced liver injury (DILI) systematically. We tried to estimate the proportion of causative materials of DILI and evaluate the clinical difference of DILIs from different materials.
Methods: Systematic searches were performed on MedRIC and MEDLIS in Korea. The extraction of data as well as selective screening of the studies was carried out independently by two of the authors. There were no restrictions on the types of publication, including grey literature.
Results: Twenty-one articles were included. Of them only 7 adapted prospective design and only 6 were published in peer-reviewed journals. The proportion of conventional drugs associated with hepatotoxic injuries in all DILI ranged from 15.8% to 83.3% and that of herbal medicine was from 28.9% to 44.7%. However, the criteria for herbal medicine were not clearly defined and concomitant medications were not fully investigated in most studies. There were limited objective data in the clinical differences of liver injuries from different materials and their results were conflicting.
Conclusions: The causality assessments regarding DILI of herbal medicine were not performed properly and causative materials were misclassified in most of the studies published in Korea. These make the safety issue still ambiguous because of the limitations and lack of objectivity of the studies. More rigorous studies are required for clearly addressing these conflicting issues with cooperative investigation between traditional Korean and western medicine.
목차
서론
연구방법
결과
고찰
결론
참고문헌
참고문헌 (48)
참고문헌 신청
1. [학술지(정기간행물)] - 이시형 / 2006 / 입원환자 한약투여와 약인성 간손상과의 관계 / 대한한방내과학회지 27 (3) : 572 ~ 578
2. [학술지(정기간행물)] - 백은경 / 2006 / 한약 장기복용이 발달장애아동의 간기능과 건강증진에 미치는 영향 / 동의생리병리학회지 20 (2) : 494 ~ 497
3. [학술지(정기간행물)] - Pittler MH / 2003 / Systematic Review : hrpatotoxic events associated with herbal medicinal products / Aliment Pharmacol Ther 18 : 451 ~ 471
4. [학술지(정기간행물)] - Joo MS / 1999 / A review of clinical characteristics and etiologic factors in patients with drug-induced hepatitis / Inha Med J 6 (1) : 1 ~ 6
5. [학술지(정기간행물)] - 천우정 / 2002 / 경주지역에서 식물제제에 의한 급성 간손상 환자의 임상적 고찰 / 대한내과학회지 63 (2) : 4 ~ 150
2. [학술지(정기간행물)] - 백은경 / 2006 / 한약 장기복용이 발달장애아동의 간기능과 건강증진에 미치는 영향 / 동의생리병리학회지 20 (2) : 494 ~ 497
3. [학술지(정기간행물)] - Pittler MH / 2003 / Systematic Review : hrpatotoxic events associated with herbal medicinal products / Aliment Pharmacol Ther 18 : 451 ~ 471
4. [학술지(정기간행물)] - Joo MS / 1999 / A review of clinical characteristics and etiologic factors in patients with drug-induced hepatitis / Inha Med J 6 (1) : 1 ~ 6
5. [학술지(정기간행물)] - 천우정 / 2002 / 경주지역에서 식물제제에 의한 급성 간손상 환자의 임상적 고찰 / 대한내과학회지 63 (2) : 4 ~ 150
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UCI(KEPA) : I410-ECN-0101-2014-519-000284418