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Current Status of N-of-1 Trials for Herbal Medicine -Literature Review
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한약에 대한 N-of-1 임상시험의 현황 – 문헌 고찰

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Type
Academic journal
Author
Chang-woon Jeung (청연중앙연구소) Sun-woo Jeon (청연중앙연구소) Hee-Geun Jo (청연중앙연구소)
Journal
Korean Oriental Medical Society The Journal of Korean Medicine Vol.41 No.1 KCI Accredited Journals
Published
2020.3
Pages
107 - 116 (10page)

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Current Status of N-of-1 Trials for Herbal Medicine -Literature Review
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Objectives: To overcome the limitations of randomized controlled trials, many other trials design is tested. The n-of-1 trial is a promising research method in the field of Korean medicine because of this methodology can examine the optimal treatment for each patient strictly. Therefore, we reviewed the status of N-of-1 studies on herbal medicine.
Methods: A systematic literature review was conducted based on the pubmed database. The search term were ‘N-of-1 Trial’, ‘Chinese Medicine’, ‘Herbal Medicine’, ‘Kampo’. There was no restriction in year.
Results: Four clinical trials have been identified to demonstrate the effectiveness of herbal medicines for Kidney-yin-deficiency syndrome, bronchiectasis and gastric cancer. These studies suggest that the N-of-1 design is a study that encourages patient involvement, demonstrates the effectiveness of herbal medicines and helps reduce unnecessary medication.
Conclusion: The N-of-1 clinical trial may be a rigorous methodology suitable for the clinical setting and may help the development of evidence-based Korean medicine. Attention is also needed in this research method in Korea.
#N-of-1 #Single Case Studies #Clinical Trial #Herbal Medicine #Korean medicine

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UCI(KEPA) : I410-ECN-0101-2020-519-000451158