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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 45 - 53 (9page)
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Korean red ginseng, the processed root of Panax ginseng Meyer, has been frequently used for various therapeutic purposes in oriental medicine. The present study investigated the possible effect of Korean red ginseng extract (RGE) for the treatment of liver fibrosis in mice injected with carbon tetrachloride (CCl4) for 4 wk. Liver injuries were assessed by blood biochemistry and histopathology in mice treated with CCl4 alone or CCl4+ RGE (30, 100, and 300 mg/kg). Concomitant treatment with RGE and CCl4 (three times/wk for 4 wk) effectively inhibited liver fibrosis as evidenced by decreases in plasma alanine and aspartate aminotransferases, as well as by the percentages of degenerative regions, numbers of degenerative hepatocytes, and collagen accumulation in hepatic parenchyma. Treatment with CCl4 for 4 wk increased mRNA levels of transforming growth factor b1 and plasminogen activator inhibitor 1 in fibrogenic liver, whereas RGE (30, 100, and 300 mg/kg) significantly blocked the induction of fibrogenic genes by CCl4. Similarly, RGE also prevented transforming growth factor b1-mediated induction of fibrogenic genes in human hepatic stellate cell lines. More importantly, RGE markedly reduced the number of a-smooth muscle actin-positive cells in liver tissue. This study implies that RGE efficaciously protects against the liver fibrosis induced by chronic CCl4 treatment, and may therefore have potential to treat liver disease.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Bataller R / 2005 / Liver fibrosis / J Clin Invest 115 : 209 ~ 218
2. [학술지(정기간행물)] - Friedman SL. / 2008 / Mechanisms of hepatic fibrogenesis / Gastroenterology 134 : 1655 ~ 1669
3. [학술지(정기간행물)] - El-Serag HB / 2007 / Hepatocellular carcinoma: epidemiology and molecular carcinogenesis / Gastroenterology 132 : 2557 ~ 2576
4. [학술지(정기간행물)] - Simonetti RG / 1991 / Hepatocellular carcinoma. A worldwide problem and the major risk factors / Dig Dis Sci 36 : 962 ~ 972
5. [학술지(정기간행물)] - Tamayo RP. / 1983 / Is cirrhosis of the liver experimentally produced by CCl4 and adequate model of human cirrhosis? / Hepatology 3 : 112 ~ 120
2. [학술지(정기간행물)] - Friedman SL. / 2008 / Mechanisms of hepatic fibrogenesis / Gastroenterology 134 : 1655 ~ 1669
3. [학술지(정기간행물)] - El-Serag HB / 2007 / Hepatocellular carcinoma: epidemiology and molecular carcinogenesis / Gastroenterology 132 : 2557 ~ 2576
4. [학술지(정기간행물)] - Simonetti RG / 1991 / Hepatocellular carcinoma. A worldwide problem and the major risk factors / Dig Dis Sci 36 : 962 ~ 972
5. [학술지(정기간행물)] - Tamayo RP. / 1983 / Is cirrhosis of the liver experimentally produced by CCl4 and adequate model of human cirrhosis? / Hepatology 3 : 112 ~ 120
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UCI(KEPA) : I410-ECN-0101-2014-524-000316383