지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 63 - 74 (12page)
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Objectives：Impulsive aggression plays a critical role in the manifestation of violent and criminal behavior in adolescents and it also is a complex behavioral phenotype. The understanding brain mechanisms underlying impulsive aggression and identification of genetic risk factors is important to the prevention and treatment of impulsive aggression. Dopaminergic system plays an active role in the modulation of aggressive behaviors and hyperactivity in the dopamine system is associated with increases in impulsive aggression. We investigated the association of the impulsive aggression in Korean adolescent prisoners with DAT1 3’-untranslated region(UTR) variable number of tandem repeat(VNTR) polymorphism.
Methods：We recruited 198 male adolescent prisoner volunteers and 68 healthy controls and investigated the dopamine transport gene(DAT1) polymorphisms. Impulsive symptoms were measured using Barratt Impulsiveness Scale (BIS) and Achenbach’s Child Behavior Checklist(CBCL). We divided all subjects into three groups by BIS, and then we compared genetic frequency and allele frequency between each subgroup.
Results：The distribution of the genotype in adolescent prisoners with 7/7, 9/10, 10/10, 10/11 were 7(3.8%), 12 (6.6%), 158(86.3%), 6(3.3%) and the controls were 2(3.2%), 5(8.1%), 52(83.9%), 3(4.8%), respectively. No significant differences for genotype distribution were revealed between adolescent prisoners and normal controls. Also there was no significant difference of genotype distribution between subgroups.
Conclusions：We failed to reveal the association between DAT1 polymorphism and impulsive aggression. In the future, larger sample size studies should continue to invest effort toward identifying the biological and genetic risk factors underlying impulsive aggression for developing effective treatment strategies.
Methods：We recruited 198 male adolescent prisoner volunteers and 68 healthy controls and investigated the dopamine transport gene(DAT1) polymorphisms. Impulsive symptoms were measured using Barratt Impulsiveness Scale (BIS) and Achenbach’s Child Behavior Checklist(CBCL). We divided all subjects into three groups by BIS, and then we compared genetic frequency and allele frequency between each subgroup.
Results：The distribution of the genotype in adolescent prisoners with 7/7, 9/10, 10/10, 10/11 were 7(3.8%), 12 (6.6%), 158(86.3%), 6(3.3%) and the controls were 2(3.2%), 5(8.1%), 52(83.9%), 3(4.8%), respectively. No significant differences for genotype distribution were revealed between adolescent prisoners and normal controls. Also there was no significant difference of genotype distribution between subgroups.
Conclusions：We failed to reveal the association between DAT1 polymorphism and impulsive aggression. In the future, larger sample size studies should continue to invest effort toward identifying the biological and genetic risk factors underlying impulsive aggression for developing effective treatment strategies.
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참고문헌
참고문헌 (69)
참고문헌 신청
1. [학술지(정기간행물)] - Valois RF / 1995 / Correlates of aggressive and violent behaviors among public high school adolescents / J Adolesc Health 16 : 26 ~ 34
3. [학술지(정기간행물)] - Moller FG / 2001 / Psychiatric Aspects of Impulsivity / Am J Psychiatry 158 : 1783 ~ 1793
4. [단행본] - Asberg M / 1987 / Psychobiology of suicide, impulsivity, and related phenomena, In Psychopharmacology: The third generation of progress / Raven Press : 655 ~ 668
5. [학술지(정기간행물)] - 이현정 / 2005 / 비행청소년들의 충동성과 뇌기능에 대한 연구 / 신경정신의학 44 (5) : 604 ~ 611
6. [학술지(정기간행물)] - Daw ND / 2002 / Opponent interactions between serotonin and dopamine / Neural Netw 15 : 603 ~ 616
3. [학술지(정기간행물)] - Moller FG / 2001 / Psychiatric Aspects of Impulsivity / Am J Psychiatry 158 : 1783 ~ 1793
4. [단행본] - Asberg M / 1987 / Psychobiology of suicide, impulsivity, and related phenomena, In Psychopharmacology: The third generation of progress / Raven Press : 655 ~ 668
5. [학술지(정기간행물)] - 이현정 / 2005 / 비행청소년들의 충동성과 뇌기능에 대한 연구 / 신경정신의학 44 (5) : 604 ~ 611
6. [학술지(정기간행물)] - Daw ND / 2002 / Opponent interactions between serotonin and dopamine / Neural Netw 15 : 603 ~ 616
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UCI(KEPA) : I410-ECN-0101-2013-513-003527905