지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 239 - 244 (6page)
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초록· 키워드
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In this study, we evaluate a method for the early diagnosis of radiodermatitis for use in the prevention and therapy of this condition. Hairless mice (SKH1-hr) were used to study the early diagnosis of radiodermatitis. Lactate dehydrogenase (LDH, EC 1.1.1.27) isozymes were analyzed using nativepolyacrylamide gel electrophoresis and western blotting of blood serum and tissues collected from SKH1- hr mice. Radiodermatitis developed 24 days after the first X-irradiation. Reduced spleen weight was observed after the last X-irradiation (P<0.05). Thereafter the weight increased until 24 days after the first irradiation, finally reaching levels comparable to those in the sham-irradiated control group. LDH activity was the highest in skeletal muscle and lowest in blood serum. LDH C<SUB>4</SUB>, A<SUB>4</SUB>, A<SUB>3</SUB>B, A<SUB>2</SUB>B<SUB>2</SUB>, AB<SUB>3</SUB>, and B<SUB>4</SUB> isozymes were detected, in the mentioned order, from the cathode. This result was similar in other mouse strains. In the irradiatedgroup, LDH A<SUB>4</SUB> isozyme levels were reduced in the serum until inflammation occurred, whereas those of B<SUB>4</SUB> isozyme were elevated. The subunits A and B followed a similar trend to that of LDH A<SUB>4</SUB> and B4 isozyme, respectively. Importantly, antibodies against LDH B<SUB>4</SUB> isozyme could prove useful in the early diagnosis of radiodermatitis.
목차
Materials and Methods
Results
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Acknowledgment
References
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UCI(KEPA) : I410-ECN-0101-2014-510-000573662