지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.9
- 수록면
- 154 - 164 (11page)
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초록· 키워드
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Purpose: This study was designed to compare outcomes in patients who underwent hepatectomy or radiofrequency thermal ablation (RFA) for synchronous or metachronous colorectal liver metastases (CLM).
Methods: One hundred twenty-two patients who underwent hepatectomy or RFA for their first CLM between 2001 and 2004 were enrolled in this study. The patients were divided into two groups (synchronous [N=77] and metachronous [N=45] CLM). Patient characteristics, clinicopathologic features, long-term outcomes, and prognostic factors were analyzed retrospectively.
Results: There were no significant differences in the 5-year disease-free and overall survival rates between the synchronous and metachronous CLM groups (36.2% vs. 37.2%, p=0.78; and 53.0% vs. 54.4%, p=0.82, respectively). Patients in the synchronous CLM group underwent more bilobar hepatic resections, intra-operative RFA, or co-modality treatments than the metachronous CLM group (p=0.035). The surgical resection group had a longer disease-free survival, but not overall survival than the RFA group. Greater N stage and female gender were associated with a worse prognosis in overall survival; N0 stage and surgical resection were good prognostic factors for disease-free survival. N stage and surgical resection were also statistically significant prognostic factors based on multivariate analysis.
Conclusion: The synchronicity of CLM is not a significant prognostic factor, but the clinicopathologic characteristics that reflect more disseminated disease than metachronous metastasis are significant prognostic factors. Tumor characteristics and aggressiveness may be more important for prognosis than chronology.
Methods: One hundred twenty-two patients who underwent hepatectomy or RFA for their first CLM between 2001 and 2004 were enrolled in this study. The patients were divided into two groups (synchronous [N=77] and metachronous [N=45] CLM). Patient characteristics, clinicopathologic features, long-term outcomes, and prognostic factors were analyzed retrospectively.
Results: There were no significant differences in the 5-year disease-free and overall survival rates between the synchronous and metachronous CLM groups (36.2% vs. 37.2%, p=0.78; and 53.0% vs. 54.4%, p=0.82, respectively). Patients in the synchronous CLM group underwent more bilobar hepatic resections, intra-operative RFA, or co-modality treatments than the metachronous CLM group (p=0.035). The surgical resection group had a longer disease-free survival, but not overall survival than the RFA group. Greater N stage and female gender were associated with a worse prognosis in overall survival; N0 stage and surgical resection were good prognostic factors for disease-free survival. N stage and surgical resection were also statistically significant prognostic factors based on multivariate analysis.
Conclusion: The synchronicity of CLM is not a significant prognostic factor, but the clinicopathologic characteristics that reflect more disseminated disease than metachronous metastasis are significant prognostic factors. Tumor characteristics and aggressiveness may be more important for prognosis than chronology.
목차
Introduction
Methods
Results
Discussion
Conclusion
References
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Boring CC / 1992 / Cancer statistics, 1992 / CA Cancer J Clin 42 : 19 ~ 38
2. [학술지(정기간행물)] - 정상훈 / 2008 / 근치적 절제 후 1년 이내 조기 재발하는 대장암 / Journal of the Korean Society of Coloproctolgy 24 (4) : 265 ~ 272
3. [학술지(정기간행물)] - Kobayashi H / 2007 / Characteristics of recurrence and surveillance tools after curative resection for colorectal cancer: a multicenter study / Surgery 141 : 67 ~ 75
4. [기타자료] - / 2000 / South and West Cancer Intelligence Unit. Wessex Colorectal Audit: Final Report, 5-Year Outcomes. Winchester: South and West Cancer Intelligence Unit
5. [학술지(정기간행물)] - Jaffe BM / 1968 / Factors influencing survival in patients with untreated hepatic metastases / Surg Gynecol Obstet 127 : 1 ~ 11
2. [학술지(정기간행물)] - 정상훈 / 2008 / 근치적 절제 후 1년 이내 조기 재발하는 대장암 / Journal of the Korean Society of Coloproctolgy 24 (4) : 265 ~ 272
3. [학술지(정기간행물)] - Kobayashi H / 2007 / Characteristics of recurrence and surveillance tools after curative resection for colorectal cancer: a multicenter study / Surgery 141 : 67 ~ 75
4. [기타자료] - / 2000 / South and West Cancer Intelligence Unit. Wessex Colorectal Audit: Final Report, 5-Year Outcomes. Winchester: South and West Cancer Intelligence Unit
5. [학술지(정기간행물)] - Jaffe BM / 1968 / Factors influencing survival in patients with untreated hepatic metastases / Surg Gynecol Obstet 127 : 1 ~ 11
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UCI(KEPA) : I410-ECN-0101-2014-514-001000264