지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.9
- 수록면
- 196 - 202 (7page)
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초록· 키워드
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Purpose: Ampulla of Vater cancer has a more favorable prognosis and survival than other malignant periampullary tumors. The pathologic staging of ampulla of Vater carcinoma is a key determinant of the patient’s prognosis. However, we have often encountered patients in whom the course of their disease differed substantially from what would be predicted based on their clinical staging, which highlights the need to consider additional predictive factors. We applied an immunohistochemical technique to examine the expression of Ki-67 and VEGF in radicallyresected ampulla of Vater carcinomas, and then compared the status of expression with several clinicopathologic factors.
Methods: Sixty-four patients who underwent curative resection for ampulla of Vater cancer between January 1992 and December 2006 at the Yonsei University College of Medicine were reviewed. The relationships between the expression of molecular markers and clinicopathologic factors were determined.
Results: There was no relationship between the clinicopathologic characteristics and the expression of molecular markers in patients with ampulla of Vater cancer. Among the clinicopathologic characteristics, lymph node metastasis was identified as an independent factor of survival after curative resection for ampulla of Vater carcinoma.
Conclusion: Measurement of Ki-67 and VEGF in patients with ampulla of Vater carcinoma may have an important role in identifying the poor prognostic group.
Methods: Sixty-four patients who underwent curative resection for ampulla of Vater cancer between January 1992 and December 2006 at the Yonsei University College of Medicine were reviewed. The relationships between the expression of molecular markers and clinicopathologic factors were determined.
Results: There was no relationship between the clinicopathologic characteristics and the expression of molecular markers in patients with ampulla of Vater cancer. Among the clinicopathologic characteristics, lymph node metastasis was identified as an independent factor of survival after curative resection for ampulla of Vater carcinoma.
Conclusion: Measurement of Ki-67 and VEGF in patients with ampulla of Vater carcinoma may have an important role in identifying the poor prognostic group.
목차
서론
방법
결과
고찰
결론
참고문헌
참고문헌 (32)
참고문헌 신청
1. [학술지(정기간행물)] - Michelassi F / 1989 / Experience with 647 consecutive tumors of the duodenum, ampulla, head of the pancreas, and distal common bile duct / Ann Surg 210 : 544 ~ 554
2. [학술지(정기간행물)] - Yeo CJ / 1998 / Periampullary adenocarcinoma: analysis of 5-year survivors / Ann Surg 227 : 821 ~ 831
3. [학술지(정기간행물)] - van der Gaag NA / 2008 / Prognostic significance of extracapsular lymph node involvement in patients with adenocarcinoma of the ampulla of Vater / Br J Surg 95 : 735 ~ 743
4. [학술지(정기간행물)] - Beghelli S / 2002 / Ampulla of vater cancers: T-stage and histological subtype but not Dpc4 expression predict prognosis / Virchows Arch 441 : 19 ~ 24
5. [학술지(정기간행물)] - Shirai Y / 1996 / Number of lymph node metastases is significantly associated with survival in patients with radically resected carcinoma of the ampulla of Vater / Br J Surg 83 : 1302 ~ 1303
2. [학술지(정기간행물)] - Yeo CJ / 1998 / Periampullary adenocarcinoma: analysis of 5-year survivors / Ann Surg 227 : 821 ~ 831
3. [학술지(정기간행물)] - van der Gaag NA / 2008 / Prognostic significance of extracapsular lymph node involvement in patients with adenocarcinoma of the ampulla of Vater / Br J Surg 95 : 735 ~ 743
4. [학술지(정기간행물)] - Beghelli S / 2002 / Ampulla of vater cancers: T-stage and histological subtype but not Dpc4 expression predict prognosis / Virchows Arch 441 : 19 ~ 24
5. [학술지(정기간행물)] - Shirai Y / 1996 / Number of lymph node metastases is significantly associated with survival in patients with radically resected carcinoma of the ampulla of Vater / Br J Surg 83 : 1302 ~ 1303
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