지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 242 - 250 (9page)
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Purpose: Splenectomy during living donor liver transplantation (LDLT) in a hepatitis C virus (HCV)-related cirrhotic recipient was performed by a Tokyo group to enhance the patient’s tolerability to post-operative anti-viral treatment by improving complete blood count (CBC) profiles. At our institution, interruption of the splenic artery (SPA) by ligation or embolization in lieu of splenectomy, has been performed in LDLT to modulate portal blood flow in small-for-size graft LDLT or to prevent rupture of SPA aneurysms in recipients. We aimed to determine if interruption of the SPA can serve as an alternative management to splenectomy in LDLT recipients based on our data.
Methods: Patients were classified into the splenic artery ligation group (SAL; n=26) and splenic artery embolization group (SAE; n=19), respectively. Among the recipients without SPA interruption, age-, gender-, and severity of cirrhosis-matched 25 recipients were selected as a control group. Post-operative CBC profiles and spleen size were reviewed retrospectively and compared between the groups.
Results: After SAL, platelet and neutrophil counts were significantly increased at 3 and 6 months, and at 1 week and 1 month, respectively (p＜0.05). After SAE, platelet and neutrophil counts were significantly increased at 3 and 6 months, and at 1 week and 3 months, respectively. There were no significant complications related to interruption of the SPA.
Conclusion: Interruption of the SPA may have a role in improving neutrophil and platelet counts in LDLT recipients with severe pancytopenia or in whom antiviral treatment for HCV in anticipated.
Methods: Patients were classified into the splenic artery ligation group (SAL; n=26) and splenic artery embolization group (SAE; n=19), respectively. Among the recipients without SPA interruption, age-, gender-, and severity of cirrhosis-matched 25 recipients were selected as a control group. Post-operative CBC profiles and spleen size were reviewed retrospectively and compared between the groups.
Results: After SAL, platelet and neutrophil counts were significantly increased at 3 and 6 months, and at 1 week and 1 month, respectively (p＜0.05). After SAE, platelet and neutrophil counts were significantly increased at 3 and 6 months, and at 1 week and 3 months, respectively. There were no significant complications related to interruption of the SPA.
Conclusion: Interruption of the SPA may have a role in improving neutrophil and platelet counts in LDLT recipients with severe pancytopenia or in whom antiviral treatment for HCV in anticipated.
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참고문헌
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - N’Kontchou G / 2005 / Partial splenic embolization in patients with cirrhosis: efficacy, tolerance and long-term outcome in 32 patients / Eur J Gastroenterol Hepatol 17 : 179 ~ 184
2. [학술지(정기간행물)] - Lisman T / 2002 / Haemostatic abnormalities in patients with liver disease / J Hepatol 37 : 280 ~ 287
3. [학술지(정기간행물)] - Berenguer M / 2006 / Efficacy, predictors of response and potential risks associated with antiviral therapy in liver transplant recipients with recurrent hepatitis C / Liver Transpl 12 : 1067 ~ 1076
4. [학술지(정기간행물)] - Neumann U / 2006 / Treatment of patients with recurrent heaptitis C after liver transplantaiton with\ peginterferon alfa-2b plus ribavirin / Transplantation 82 : 43 ~ 47
5. [학술지(정기간행물)] - Lee CM / 2007 / Evaluation of the effect of partial splenic embolization on platelet values for liver cirrhosis patients with thrombocytopenia / World J Gastroenterol 13 : 619 ~ 622
2. [학술지(정기간행물)] - Lisman T / 2002 / Haemostatic abnormalities in patients with liver disease / J Hepatol 37 : 280 ~ 287
3. [학술지(정기간행물)] - Berenguer M / 2006 / Efficacy, predictors of response and potential risks associated with antiviral therapy in liver transplant recipients with recurrent hepatitis C / Liver Transpl 12 : 1067 ~ 1076
4. [학술지(정기간행물)] - Neumann U / 2006 / Treatment of patients with recurrent heaptitis C after liver transplantaiton with\ peginterferon alfa-2b plus ribavirin / Transplantation 82 : 43 ~ 47
5. [학술지(정기간행물)] - Lee CM / 2007 / Evaluation of the effect of partial splenic embolization on platelet values for liver cirrhosis patients with thrombocytopenia / World J Gastroenterol 13 : 619 ~ 622
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UCI(KEPA) : I410-ECN-0101-2014-514-001253405