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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.9
- 수록면
- 171 - 179 (9page)
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Diabetes decreases skeletal muscle mass and induces atrophy. However, the mechanisms by which hyperglycemia and insulin deficiency modify muscle mass are not well defined. In this study, we evaluated the effects of swimming exercise on muscle mass and intracellular protein degradation in diabetic rats, and proposed that autophagy inhibition induced by swimming exercise serves as a hypercatabolic mechanism in the skeletal muscles of diabetic rats, supporting a notion that swimming exercise could efficiently reverse the reduced skeletal muscle mass caused by diabetes. Adult male Sprague-Dawley rats were injected intraperitoneally with streptozotocin (60 mg/kg body weight) to induce diabetes and then submitted to 1 hr per day of forced swimming exercise, 5 days per week for 4 weeks. We conducted an intraperitoneal glucose tolerance test on the animals and measured body weight, skeletal muscle mass, and protein degradation and examined the level of autophagy in the isolated extensor digitorum longus, plantaris, and soleus muscles. Body weight and muscle tissue mass were higher in the exercising diabetic rats than in control diabetic rats that remained sedentary. Compared to control rats, exercising diabetic rats had lower blood glucose levels, increased intracellular contractile protein expression, and decreased autophagic protein expression. We conclude that swimming exercise improves muscle mass in diabetes-induced skeletal muscle atrophy, suggesting the activation of autophagy in diabetes contributes to muscle atrophy through hypercatabolic metabolism and that aerobic exercise, by suppressing autophagy, may modify or reverse skeletal muscle wasting in diabetic patients.
목차
Materials and Methods
Results
Discussion
Acknowledgment
References
참고문헌 (44)
참고문헌 신청
Sun Z / 2008 / Muscular response and adaptation to diabetes mellitus / Front Biosci 13:4765~4794
Lecker SH / 1999 / Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states / J Nutr 129(1S Suppl):227S~237S
Emery PW / 1999 / Cachexia in experimental models / Nutrition 15(7):600~603
Costelli P / 2000 / Cancer cachexia: from experimental models to patient management / Curr Opin Clin Nutr Metab Care 3(3):177~181
Attaix D / 1999 / Adaptation of the ubiquitin-proteasome proteolytic pathway in cancer cachexia / Mol Biol Rep 26(1):77~82
Lecker SH / 1999 / Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states / J Nutr 129(1S Suppl):227S~237S
Emery PW / 1999 / Cachexia in experimental models / Nutrition 15(7):600~603
Costelli P / 2000 / Cancer cachexia: from experimental models to patient management / Curr Opin Clin Nutr Metab Care 3(3):177~181
Attaix D / 1999 / Adaptation of the ubiquitin-proteasome proteolytic pathway in cancer cachexia / Mol Biol Rep 26(1):77~82
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UCI(KEPA) : I410-ECN-0101-2014-510-001260386