지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.9
- 수록면
- 98 - 104 (7page)
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초록· 키워드
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Backgrounds/Aims: Although recent advances in surgical techniques and alternative treatment, the long-term survival ＞5 years after liver resection for hepatocellular carcinoma (HCC) is still unsatisfactory due to the high recurrence rate compared with other solid organ cancers. This study was conducted to analyze long-term survival after HCC resection and to develop an optimal strategy to achieve long-term survival. Methods: A retrospective review was performed for HCC patients who underwent liver resection between 1996 and 2006. The survival rates and prognostic factors were assessed. The clinical and pathological factors of patients who survived more than 5 years were compared with those of patients whose survival was less than 5 years. The clinicopathological features characterizing long-term survivors were also reviewed. Results: The overall and disease-free 5-year survival rates of 87 cases were 38.5% and 29.4%, respectively. Twenty-seven of 87 patients survived longer than 5 years after liver resection. The univariate analysis revealed that hepatitis C, the serum aspartate sminotransferase (AST) level, liver cirrhosis, Edmondson-Steiner grade, AJCC stage, and vascular invasion were significant factors for overall survival, and serum AST level, liver cirrhosis, Edmondson-Steiner grade, AJCC stage, and vascular invasion were the affecting factors for disease-free survival. In multivariate analysis, serum AST level, hepatitis C and vascular invasion were related with the overall survival, liver cirrhosis and vascular invasion which were associated with disease-free survival. Vascular invasion, AJCC stage, and the Edmondson-Steiner grade were significant factors in long-term survivors. Conclusions: Patients without liver cirrhosis, vascular invasion and normal liver function, good differentiation and an early stage may be expected to have a long-term survival.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Nagasue N / 1993 / Incidence and factors associated with intrahepatic recurrence following resection of hepatocellular carcinoma / Gastroenterology 105 : 488 ~ 494
2. [학술지(정기간행물)] - 노무정 / 2009 / 간세포암의 근치적 간절제술 후 장기생존과 연관된 예후인자 / 대한외과학회지 76 (4) : 225 ~ 230
3. [학술지(정기간행물)] - Ibrahim S / 2007 / Risk factors for intrahepatic recurrence after hepatectomy for hepatocellular carcinoma / Am J Surg 194 : 17 ~ 22
4. [학술지(정기간행물)] - Nagasue N / 2001 / Prognostic factors and survival after hepatic resection for hepatocellular carcinoma without cirrhosis / Br J Surg 88 : 515 ~ 522
5. [학술지(정기간행물)] - Marelli L / 2006 / Treatment outcomes for hepatocellular carcinoma using chemoembolization in combination with other therapies / Cancer Treat Rev 32 : 594 ~ 606
2. [학술지(정기간행물)] - 노무정 / 2009 / 간세포암의 근치적 간절제술 후 장기생존과 연관된 예후인자 / 대한외과학회지 76 (4) : 225 ~ 230
3. [학술지(정기간행물)] - Ibrahim S / 2007 / Risk factors for intrahepatic recurrence after hepatectomy for hepatocellular carcinoma / Am J Surg 194 : 17 ~ 22
4. [학술지(정기간행물)] - Nagasue N / 2001 / Prognostic factors and survival after hepatic resection for hepatocellular carcinoma without cirrhosis / Br J Surg 88 : 515 ~ 522
5. [학술지(정기간행물)] - Marelli L / 2006 / Treatment outcomes for hepatocellular carcinoma using chemoembolization in combination with other therapies / Cancer Treat Rev 32 : 594 ~ 606
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UCI(KEPA) : I410-ECN-0101-2014-514-001348683