지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.4
- 수록면
- 225 - 230 (6page)
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초록· 키워드
오류제보하기
Purpose: Although advancement in treatment and diagnostic tools related to hepatocelluar carcinoma has been much improved, long term survival rates of hepatocellular carcinoma are still low because of delayed clinical manifestations and underlying diseases causing the cancer. Various kinds of modalities to treat hepatocellular carcinoma have developed but surgical resection is still recognized as the best method. Therefore, we studied the associated factors of long-term survival after liver resection.
Methods: We retrospectively analyzed 184 patients who were pathologically diagnosed with hepatocellular carcinoma from May 1990 to December 2002. Associated factors of long-term survival classified as preoperative, operative, pathological and recurrence factors. Univariate and multivariate analyses were done using cross tabulation analysis and logistic regression analysis.
Results: The cumulative 1??, 3?? and 5??year survival rates were 66%, 50% and 30%, respectively. Preoperative factors, significantly associated with long-term survival, were age of 60 years and under, tumor size, HBe Ag status and preoperative tumor marker level. As pathological factors, the vascular invasion and lymphatic invasion status were significantly associated. But cirrhosis of the liver was not associated with long-term survival. And in cases of recurrence, patients who had undergone repeat resection survived significantly longer.
Conclusion: The most significant factors of multivariate analyses were lymphatic invasion status. Tumor size, ICG?R15 and HBe Ag status followed second. We should correct the preoperative factors through screening and early diagnosis. And when recurrence occurs, if the recurring cancer has resectability, repeat hepatectomy will increase the patient"s lifespan.
Methods: We retrospectively analyzed 184 patients who were pathologically diagnosed with hepatocellular carcinoma from May 1990 to December 2002. Associated factors of long-term survival classified as preoperative, operative, pathological and recurrence factors. Univariate and multivariate analyses were done using cross tabulation analysis and logistic regression analysis.
Results: The cumulative 1??, 3?? and 5??year survival rates were 66%, 50% and 30%, respectively. Preoperative factors, significantly associated with long-term survival, were age of 60 years and under, tumor size, HBe Ag status and preoperative tumor marker level. As pathological factors, the vascular invasion and lymphatic invasion status were significantly associated. But cirrhosis of the liver was not associated with long-term survival. And in cases of recurrence, patients who had undergone repeat resection survived significantly longer.
Conclusion: The most significant factors of multivariate analyses were lymphatic invasion status. Tumor size, ICG?R15 and HBe Ag status followed second. We should correct the preoperative factors through screening and early diagnosis. And when recurrence occurs, if the recurring cancer has resectability, repeat hepatectomy will increase the patient"s lifespan.
목차
서론
방법
결과
고찰
REFERENCES
참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Kim GS / 1999 / Long-term survival rates and prognostic factors for a hepatocellular carcinoma after a curative hepatic resection / J Korean Surg Soc 57 : 715 ~ 727
2. [학술지(정기간행물)] - MacIntosh EL / 1992 / Hepatic resection in patients with cirrhosis and hepatocellular carcinoma / Surg Gynecol Obstet 174 : 245 ~ 254
3. [단행본] - Ministry of Health and Welfare / 2007 / Yearbook of Health & Welfare Statistics / Ministry of Health and Welfare
4. [학술지(정기간행물)] - Makuuchi M / 1985 / Ultrasonically guided subsegmentectomy / Surg Gynecol Obstet 161 : 346 ~ 350
5. [학술지(정기간행물)] - Imamura H / 1999 / Prognostic significance of anatomical resection and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma / Br J Surg 86 : 1032 ~ 1038
2. [학술지(정기간행물)] - MacIntosh EL / 1992 / Hepatic resection in patients with cirrhosis and hepatocellular carcinoma / Surg Gynecol Obstet 174 : 245 ~ 254
3. [단행본] - Ministry of Health and Welfare / 2007 / Yearbook of Health & Welfare Statistics / Ministry of Health and Welfare
4. [학술지(정기간행물)] - Makuuchi M / 1985 / Ultrasonically guided subsegmentectomy / Surg Gynecol Obstet 161 : 346 ~ 350
5. [학술지(정기간행물)] - Imamura H / 1999 / Prognostic significance of anatomical resection and des-gamma-carboxy prothrombin in patients with hepatocellular carcinoma / Br J Surg 86 : 1032 ~ 1038
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UCI(KEPA) : I410-ECN-0101-2013-514-002687525