지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.6
- 수록면
- 433 - 437 (5page)
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이 논문의 연구 히스토리 (2)
2007
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Purpose: Considering the complications of nonspecific immunosuppression, as well as the availability of insulin, heavy immunosuppressive treatment to pancreatic islet transplantation patients is not justified. Antigen administration via the portal vein has been demonstrated to induce immunosuppression, and may present a possible mechanism for the induction of tolerance. Using a mouse model, without any immunosuppressive treatment, the islet allograft survivals were compared between portal venous transfusion and portal venous saline injection groups.
Methods: Six C57BL/6J mice were used as pancreatic islet donors per Balb/c recipient mouse. Islets were harvested by digestion of the pancreata with collagenase, with subsequent Ficoll density gradient separation. Recipient mice were divided into two groups: seven mice received a portal venous injection of 0.1 cc saline (PVS) and eight a portal venous transfusion of 0.1 cc donor blood (PVT). Islets were transplanted into the subcapsular space of the left kidney. Transplantation failure was determined if the transplanted mouse failed to show a blood glucose level less than 200 ㎎/㎗ at 24 hours after the transplantation; these mice were not included in the statistics. Rejection was determined when the normalized blood glucose level (＜200 ㎎/㎗) returned to above 300 ㎎/㎗.
Results: The mean islet equivalent numbers (IEQ) of the seven PVS and eight PVT mice were 893±262 and 911±288, respectively. The islet allograft survival of the PVS group ranged between 1 to 9 days; whereas, that of the PVT group ranged between 6 to 16 days. The PVT group showed significantly higher islet allograft survival than the PVS group (P=0.0443).
Conclusion: A portal venous transfusion prolonged the islet allograft survival.
Methods: Six C57BL/6J mice were used as pancreatic islet donors per Balb/c recipient mouse. Islets were harvested by digestion of the pancreata with collagenase, with subsequent Ficoll density gradient separation. Recipient mice were divided into two groups: seven mice received a portal venous injection of 0.1 cc saline (PVS) and eight a portal venous transfusion of 0.1 cc donor blood (PVT). Islets were transplanted into the subcapsular space of the left kidney. Transplantation failure was determined if the transplanted mouse failed to show a blood glucose level less than 200 ㎎/㎗ at 24 hours after the transplantation; these mice were not included in the statistics. Rejection was determined when the normalized blood glucose level (＜200 ㎎/㎗) returned to above 300 ㎎/㎗.
Results: The mean islet equivalent numbers (IEQ) of the seven PVS and eight PVT mice were 893±262 and 911±288, respectively. The islet allograft survival of the PVS group ranged between 1 to 9 days; whereas, that of the PVT group ranged between 6 to 16 days. The PVT group showed significantly higher islet allograft survival than the PVS group (P=0.0443).
Conclusion: A portal venous transfusion prolonged the islet allograft survival.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Bertuzzi F / 2006 / Islet cell transplantation / Curr Mol Med 6 : 369 ~ 374
2. [학술지(정기간행물)] - Lee TC / 2006 / The effect of whole organ pancreas transplantation and PIT on diabetic complications / Curr Diab Rep 6 : 323 ~ 327
3. [학술지(정기간행물)] - Pavlakis M / 2006 / Transplantation for type 1 diabetes: whole organ pancreas and islet cells / Curr Diab Rep 6 : 473 ~ 478
4. [학술지(정기간행물)] - Pileggi A / 2006 / Overcoming the challenges now limiting islet transplantation: a sequential, integrated approach / Ann N Y Acad Sci 1079 : 383 ~ 398
5. [학술지(정기간행물)] - Stagner JI / 2006 / Remission of digestive insufficiency by islet transplantation to the pancreas / Dig Dis Sci 51 : 1777 ~ 1779
2. [학술지(정기간행물)] - Lee TC / 2006 / The effect of whole organ pancreas transplantation and PIT on diabetic complications / Curr Diab Rep 6 : 323 ~ 327
3. [학술지(정기간행물)] - Pavlakis M / 2006 / Transplantation for type 1 diabetes: whole organ pancreas and islet cells / Curr Diab Rep 6 : 473 ~ 478
4. [학술지(정기간행물)] - Pileggi A / 2006 / Overcoming the challenges now limiting islet transplantation: a sequential, integrated approach / Ann N Y Acad Sci 1079 : 383 ~ 398
5. [학술지(정기간행물)] - Stagner JI / 2006 / Remission of digestive insufficiency by islet transplantation to the pancreas / Dig Dis Sci 51 : 1777 ~ 1779
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