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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.8
- 수록면
- 87 - 95 (9page)
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Purpose: HER-2/neu is the most frequently amplified oncogene in breast cancer. Topoisomerase Ⅱ-α is a key enzyme in DNA replication and it is a molecular target for many anti-cancer drugs that are called topo Ⅱ inhibitors; in addition, it is a new marker of proliferation. Because of the physical proximity of the ER-2/neu and topoisomerase Ⅱ-α genes, co-amplification of the HER-2/neu and topoisomerase Ⅱ-α may be important determinates of the response to chemotherapy for advanced breast cancer patients.
Methods: We studied the correlation of gene amplification of HER-2/neu and topoisomerase Ⅱ-α by chromogenic in situ hybridization (CISH) in 43 infiltrating duct carcinomas of the breast. The over-expression of HER-2/neu protein and the staining index for the proliferation marker of topoisomerase Ⅱ-α were examined immunohistochemically. The correlations between the status of HER-2/neu and topoisomerase Ⅱ-α and the other clinicopathologic variables such as tumor size, lymph node metastasis, TNM stage, histologic grade, nuclear grade, and the estrogen receptor and progesteron receptor were investigated.
Results: Of the 43 infiltrating ductal carcinomas, the amplifications of HER-2/neu and topoisomerase Ⅱ-α by CISH were observed in 8 cases (18.6%) and 14 cases (32.6%), respectively. Amplification of HER-2/neu showed the statistically significant correlations with tumor size, histologic grade and the topoisomerase Ⅱ-α staining index. Amplification of topoisomerase Ⅱ-α showed statistically significant correlations with axillary lymph node metastasis, the stage, the nuclear grade and the estrogen receptor status.
Conclusion: These data suggest that amplification of HER-2/neu oncogene and topoisomerase Ⅱ-α by CISH may be valuable for determining the response to chemotherapy, and detection of HER-2/neu and topoisomerase Ⅱ-α in tumor sections may have prognostic value in human breast cancer.
Methods: We studied the correlation of gene amplification of HER-2/neu and topoisomerase Ⅱ-α by chromogenic in situ hybridization (CISH) in 43 infiltrating duct carcinomas of the breast. The over-expression of HER-2/neu protein and the staining index for the proliferation marker of topoisomerase Ⅱ-α were examined immunohistochemically. The correlations between the status of HER-2/neu and topoisomerase Ⅱ-α and the other clinicopathologic variables such as tumor size, lymph node metastasis, TNM stage, histologic grade, nuclear grade, and the estrogen receptor and progesteron receptor were investigated.
Results: Of the 43 infiltrating ductal carcinomas, the amplifications of HER-2/neu and topoisomerase Ⅱ-α by CISH were observed in 8 cases (18.6%) and 14 cases (32.6%), respectively. Amplification of HER-2/neu showed the statistically significant correlations with tumor size, histologic grade and the topoisomerase Ⅱ-α staining index. Amplification of topoisomerase Ⅱ-α showed statistically significant correlations with axillary lymph node metastasis, the stage, the nuclear grade and the estrogen receptor status.
Conclusion: These data suggest that amplification of HER-2/neu oncogene and topoisomerase Ⅱ-α by CISH may be valuable for determining the response to chemotherapy, and detection of HER-2/neu and topoisomerase Ⅱ-α in tumor sections may have prognostic value in human breast cancer.
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UCI(KEPA) : I410-ECN-0101-2013-514-002673221