지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.9
- 수록면
- 204 - 209 (6page)
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Purpose: Various prognostic indicators have been identified for mammary carcinomas, but the issue of their significance remains unsettled. The prognostic impact of c-erb B2, Ki-67 and topoisomerase Ⅱ α expression was investigated in relation to prognostic factors for carcinomas of the breast and to the tumor cell growth fraction.
Methods: One hundred eighteen cases of invasive mammary carcinoma were investigated by immunohistochemical staining for c-erb B2, topoisomerase Ⅱ α, and Ki-67. Clinicopathologic parameters were compared with the expression pattern and incidence of c-erb B2, topoisomerase Ⅱ α and Ki-67 in invasive mammary carcinoma.
Results: C-erb B2 showed significant correlation with topoisomerase Ⅱ α (P＜0.05), but others were not significant. Topoisomerase Ⅱ α and Ki-67 index closely paralleled each other, indicating that both reflect the proliferate activity of tumor cells and were associated with high nuclear and histological grade, ER and PR expression (P＜0.05).
Conclusion: These results indicate that ki-67 and topoisomerase Ⅱ α proteins might play a role in tumor progression of breast carcinoma. The Ki-67 and topoisomerase Ⅱ α index may be proliferate factors of breast cancer. In addition, the increase expression of Ki-67 and topoisomerase Ⅱ α and hormone receptor were closely correlated each other, and could be used as factors suggesting poor prognosis in breast carcinoma.
Methods: One hundred eighteen cases of invasive mammary carcinoma were investigated by immunohistochemical staining for c-erb B2, topoisomerase Ⅱ α, and Ki-67. Clinicopathologic parameters were compared with the expression pattern and incidence of c-erb B2, topoisomerase Ⅱ α and Ki-67 in invasive mammary carcinoma.
Results: C-erb B2 showed significant correlation with topoisomerase Ⅱ α (P＜0.05), but others were not significant. Topoisomerase Ⅱ α and Ki-67 index closely paralleled each other, indicating that both reflect the proliferate activity of tumor cells and were associated with high nuclear and histological grade, ER and PR expression (P＜0.05).
Conclusion: These results indicate that ki-67 and topoisomerase Ⅱ α proteins might play a role in tumor progression of breast carcinoma. The Ki-67 and topoisomerase Ⅱ α index may be proliferate factors of breast cancer. In addition, the increase expression of Ki-67 and topoisomerase Ⅱ α and hormone receptor were closely correlated each other, and could be used as factors suggesting poor prognosis in breast carcinoma.
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REFERENCES
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Been ken SW / 2001 / Mo55lecular biomarkers for breast cancer prognosis: co expression of c-erbB-2 and p.53 / Ann Surg 233 : 630 ~ 638
2. [학술지(정기간행물)] - Lynch BJ / 1997 / Human DNA topoisomerase II-alpha: a new marker of cell proliferation in invasive breast cancer / Hum Pathol 28 : 1180 ~ 1188
3. [학술지(정기간행물)] - Hirabayashi S. / 1999 / Immunohistochemical detection of DNA topoisomerase type II alpha and Ki-67 in adenoid cystic carcinoma and pleomorphic adenoma of the salivary gland / J Oral Pathol Med 28 : 131 ~ 136
4. [학술지(정기간행물)] - Harris LN / 2001 / Induction of topoisomerase II activity after ErbB2 activation is associated with a differential response to breast cancer chemotherapy / Clin Cancer Res 7 : 1497 ~ 1504
5. [학술지(정기간행물)] - Le Doussal V / 1989 / Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas / Cancer 64 : 1914 ~ 1921
2. [학술지(정기간행물)] - Lynch BJ / 1997 / Human DNA topoisomerase II-alpha: a new marker of cell proliferation in invasive breast cancer / Hum Pathol 28 : 1180 ~ 1188
3. [학술지(정기간행물)] - Hirabayashi S. / 1999 / Immunohistochemical detection of DNA topoisomerase type II alpha and Ki-67 in adenoid cystic carcinoma and pleomorphic adenoma of the salivary gland / J Oral Pathol Med 28 : 131 ~ 136
4. [학술지(정기간행물)] - Harris LN / 2001 / Induction of topoisomerase II activity after ErbB2 activation is associated with a differential response to breast cancer chemotherapy / Clin Cancer Res 7 : 1497 ~ 1504
5. [학술지(정기간행물)] - Le Doussal V / 1989 / Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas / Cancer 64 : 1914 ~ 1921
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UCI(KEPA) : I410-ECN-0101-2013-514-002673089