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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 163 - 170 (8page)
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Purpose: Sentinel lymph node biopsy (SLNB) is a minimally invasive procedure to avoid axillary dissection in breast cancer patients without axillary lymph node involvement, although there is no standardization of the technique. The aims of this study were to evaluate the efficacy of SLNB using radioisotopes in predicting axillary lymph node status, and to asses the clinical indications of SLNB.
Methods: We conducted a prospective study of SLNB performed at Chonbuk National University Hospital between February 2000 and August 2005. All patients underwent SLNB, followed by planned completion axillary dissection regardless of the SLNB results. For identification of SLN, a radioisotope was used as a tracer with a peritumoral or subareolar injection, and SLNB using a gamma probe was performed after preoperative lymphoscintigraphy.
Results: The sentinel lymph nodes were identified in 68 of the 70 patients (97.1%), with a mean of 2.84 sentinel nodes per patient. Overall, sensitivity was 83.3% (30/36), specificity 100% (32/32), accuracy 91.2% (62/68), and negative predictive value 84.2% (32/38). The false negative rate was 16.7% (6/36), and there was a significant difference in preoperative radiologic findings for axillary lymph node status (P=0.005).
Conclusion: Compared with peritumoral injection, SLNB using a subareolar injection of a radioisotope was an accurate alternative to complete axillary dissection. SLNB may be indicated when there is no evidence of axillary lymph node metastasis in the preoperative radiologic examination.
Methods: We conducted a prospective study of SLNB performed at Chonbuk National University Hospital between February 2000 and August 2005. All patients underwent SLNB, followed by planned completion axillary dissection regardless of the SLNB results. For identification of SLN, a radioisotope was used as a tracer with a peritumoral or subareolar injection, and SLNB using a gamma probe was performed after preoperative lymphoscintigraphy.
Results: The sentinel lymph nodes were identified in 68 of the 70 patients (97.1%), with a mean of 2.84 sentinel nodes per patient. Overall, sensitivity was 83.3% (30/36), specificity 100% (32/32), accuracy 91.2% (62/68), and negative predictive value 84.2% (32/38). The false negative rate was 16.7% (6/36), and there was a significant difference in preoperative radiologic findings for axillary lymph node status (P=0.005).
Conclusion: Compared with peritumoral injection, SLNB using a subareolar injection of a radioisotope was an accurate alternative to complete axillary dissection. SLNB may be indicated when there is no evidence of axillary lymph node metastasis in the preoperative radiologic examination.
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REFERENCES
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Moore MP / 1997 / Axillary lymphadenectomy: a diagnostic and therapeutic procedure / J Surg Oncol 66 : 2 ~ 6
2. [학술지(정기간행물)] - Morton DL / 1992 / Technical details of intraoperative lymphatic mapping for early stage melanoma / Arch Surg 127 : 392 ~ 399
3. [학술지(정기간행물)] - Giuliano AE / 1994 / Lymphatic mapping and sentinel lymphadenedtomy for breast cancer / Ann Surg 220 : 391 ~ 398
4. [학술지(정기간행물)] - Mendez JE / 2005 / Can sentinel lymph node biopsy be omitted in patients with favorable breast cancer histology? / Ann Surg Oncol 12 : 24 ~ 28
5. [학술지(정기간행물)] - Yang JH / 2000 / Clinical application of sentinel node biopsy in T1 or less breast cancers - is it effective or feasible? / J Korean Surg Soc 58 : 29 ~ 33
2. [학술지(정기간행물)] - Morton DL / 1992 / Technical details of intraoperative lymphatic mapping for early stage melanoma / Arch Surg 127 : 392 ~ 399
3. [학술지(정기간행물)] - Giuliano AE / 1994 / Lymphatic mapping and sentinel lymphadenedtomy for breast cancer / Ann Surg 220 : 391 ~ 398
4. [학술지(정기간행물)] - Mendez JE / 2005 / Can sentinel lymph node biopsy be omitted in patients with favorable breast cancer histology? / Ann Surg Oncol 12 : 24 ~ 28
5. [학술지(정기간행물)] - Yang JH / 2000 / Clinical application of sentinel node biopsy in T1 or less breast cancers - is it effective or feasible? / J Korean Surg Soc 58 : 29 ~ 33
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UCI(KEPA) : I410-ECN-0101-2013-514-002693429