지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.4
- 수록면
- 243 - 247 (5page)
이용수
초록· 키워드
오류제보하기
Purpose: Experimental animal models are useful training methods for liver transplantation, despite of ethical issues. The aims of this study are to examine the technical feasibility of living donor liver transplantation in pigs and to address the ethical problems.
Methods: Eight pigs were used in this experiment. The pig liver was divided via a left hemi-hepatectomy without inflow occlusion. The GORE-TEX<SUP>R</SUP> Vascular Graft was used as a replacement for the inferior vena cava during the graft. After the bench technique, the remnant right lobe of the pig was removed. During the anhepatic phase, an abdominal aortic clamp in combination with general hypothermia was applied, instead of using a conventional bypass procedure.
Results: Anhepatic time was 41.3±7.0 min and cold ischemic time was 200.3±29.4 min. The 1<SUP>st</SUP>, 4<SUP>th</SUP>, and 8<SUP>th</SUP> pig died because of declamping shock and arrhythmia on releasing the abdominal aortic clamp. Three pigs had five postoperative complications: pneumonia, gastrointestinal bleeding, IVC thrombosis, portal vein thrombosis, and bile duct stricture. The 6th pig received a hepaticojejunostomy due to stricture of the anastomosis site at 37 days after transplantation.
Conclusion: Pigs are economically and ethically more convenient compared to primate models. For auto-liver transplantation, no immunotherapy was needed. The pigs lived relatively long, allowing operative faults to be detected and studied. This experimental model will be useful training for living donor liver transplantation.
Methods: Eight pigs were used in this experiment. The pig liver was divided via a left hemi-hepatectomy without inflow occlusion. The GORE-TEX<SUP>R</SUP> Vascular Graft was used as a replacement for the inferior vena cava during the graft. After the bench technique, the remnant right lobe of the pig was removed. During the anhepatic phase, an abdominal aortic clamp in combination with general hypothermia was applied, instead of using a conventional bypass procedure.
Results: Anhepatic time was 41.3±7.0 min and cold ischemic time was 200.3±29.4 min. The 1<SUP>st</SUP>, 4<SUP>th</SUP>, and 8<SUP>th</SUP> pig died because of declamping shock and arrhythmia on releasing the abdominal aortic clamp. Three pigs had five postoperative complications: pneumonia, gastrointestinal bleeding, IVC thrombosis, portal vein thrombosis, and bile duct stricture. The 6th pig received a hepaticojejunostomy due to stricture of the anastomosis site at 37 days after transplantation.
Conclusion: Pigs are economically and ethically more convenient compared to primate models. For auto-liver transplantation, no immunotherapy was needed. The pigs lived relatively long, allowing operative faults to be detected and studied. This experimental model will be useful training for living donor liver transplantation.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (11)
참고문헌 신청
1. [학술지(정기간행물)] - Welch CS / 1955 / A note on transplantation of the whole liver in dogs / Transplant Bull 2 : 54 ~
2. [학술지(정기간행물)] - Kawarasaki H / 1994 / Partial liver transplantation from a living donor: Experimental research and clinical experience / J Pediatr Surg 29 : 518 ~ 523
3. [학술지(정기간행물)] - Hayashi S / / Combination splitting using both in situ and ex situ techniques in triple split liver transplantation in pigs / Transpl Int 11 : 408 ~ 412
4. [학술지(정기간행물)] - Nardo B / 1999 / Porcine living liver transplantation using vascular prosthesis to replace the intrahepatic vena cava / Eur Surg Res 31 : 364 ~ 370
5. [단행본] - Starzl TE / 1992 / The Puzzle People: Memoris of a Transplant Surgeon / University of Pittsuburg Press
2. [학술지(정기간행물)] - Kawarasaki H / 1994 / Partial liver transplantation from a living donor: Experimental research and clinical experience / J Pediatr Surg 29 : 518 ~ 523
3. [학술지(정기간행물)] - Hayashi S / / Combination splitting using both in situ and ex situ techniques in triple split liver transplantation in pigs / Transpl Int 11 : 408 ~ 412
4. [학술지(정기간행물)] - Nardo B / 1999 / Porcine living liver transplantation using vascular prosthesis to replace the intrahepatic vena cava / Eur Surg Res 31 : 364 ~ 370
5. [단행본] - Starzl TE / 1992 / The Puzzle People: Memoris of a Transplant Surgeon / University of Pittsuburg Press
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