지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
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- 46 - 50 (5page)
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Purpose: To overcome donor shortage, reduced-size liver transplantation, spilt-liver transplantation and partial liver transplantation from living donors for children are frequently used all over the world. Despite the difficulties of a adequate volume reduction and the age difference between donor and the recipient, all these techniques also share the problem of size mismatch between the vessels of the adult liver and those of the pediatric recipient. portal vein reconstruction in a crucial factor for a successful transplantation because it allows blood flow to the liver graft, which ends the ischemic period for the graft, as well as the anhepatic period for the recipient.
Methods: In GroupⅠ(n=10, no growth factor), a partial liver of Sprague-Dqwley(SD) rat was transplanted heterotopically, via microsurgical technique, to a SD rat with performing end-to-end portal vein anastomosis without applying growth factor to the suture of the portal vein. In GroupⅡ(n=10, 50-60% growth factor), a partial liver of a SD rat was trnasplanted heterotopically to a SD rat, via microsurgical technique, with applying growth factor to 50-60% of the diameter of the portal vein. In GroupⅢ(n=10, 80-100% growth factor), the portal vein was anastomosed, via microsurgical technique, with using growth factor to 80-100% of the diameter of the portal vein.
Results: In GroupⅡ, only one case has portal vein stenosis on the postoperative 14th day following portal vein anastomosis with growth factor. In GroupⅠ, 3 cases showed portal vein stenosis on the postoperative 7th day, and 5 cases showed portal vein thrombosis on the postoperative 14th day. In GroupⅢ, 6 cases died due to bleeding after declamping of the portal vein anastomosis with using 80-100% growth factor on the diameter and 1 case has portal vein thrombosis on the postoperative 14th day.
Conclusion: Several surgical factors might have an important role in preventing vascular stenosis and thrombosis, and especially when transplanting a technical-variant liver graft like a difference in caliber between the donor and recipient vessels, the growth-factor suture technique having 50-60% of one diameter might be helpful because it allows for expansion along the suture line and it also prevents a purse-string effect.
Methods: In GroupⅠ(n=10, no growth factor), a partial liver of Sprague-Dqwley(SD) rat was transplanted heterotopically, via microsurgical technique, to a SD rat with performing end-to-end portal vein anastomosis without applying growth factor to the suture of the portal vein. In GroupⅡ(n=10, 50-60% growth factor), a partial liver of a SD rat was trnasplanted heterotopically to a SD rat, via microsurgical technique, with applying growth factor to 50-60% of the diameter of the portal vein. In GroupⅢ(n=10, 80-100% growth factor), the portal vein was anastomosed, via microsurgical technique, with using growth factor to 80-100% of the diameter of the portal vein.
Results: In GroupⅡ, only one case has portal vein stenosis on the postoperative 14th day following portal vein anastomosis with growth factor. In GroupⅠ, 3 cases showed portal vein stenosis on the postoperative 7th day, and 5 cases showed portal vein thrombosis on the postoperative 14th day. In GroupⅢ, 6 cases died due to bleeding after declamping of the portal vein anastomosis with using 80-100% growth factor on the diameter and 1 case has portal vein thrombosis on the postoperative 14th day.
Conclusion: Several surgical factors might have an important role in preventing vascular stenosis and thrombosis, and especially when transplanting a technical-variant liver graft like a difference in caliber between the donor and recipient vessels, the growth-factor suture technique having 50-60% of one diameter might be helpful because it allows for expansion along the suture line and it also prevents a purse-string effect.
목차
서론
재료 및 방법
결과
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참고문헌
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Gross JA / 1998 / Long-term results of pediatric liver transplantation: An analysis of 569 transplants / Ann Surg 228 : 411 ~ 420
2. [학술지(정기간행물)] - Yersiz H / 2003 / One Hundred In Situ Split-Liver Transplantations: A Single-Center Experience / Ann Surg 238 : 411 ~ 420
3. [학술지(정기간행물)] - Saad S / 1998 / Portal vein reconstruction in pediatric liver transplantation from living donors / Ann Surg 227 : 275 ~ 281
4. [학술지(정기간행물)] - Cacciarelli TV / 1997 / Factors affecting survival after orthotopic liver transplantation in infants / Transplantation 64 : 242 ~ 248
5. [학술지(정기간행물)] - Millis JM / 1996 / Portal vein thrombosis and stenosis in pediatric liver transplantation / Transplantation 62 : 748 ~ 754
2. [학술지(정기간행물)] - Yersiz H / 2003 / One Hundred In Situ Split-Liver Transplantations: A Single-Center Experience / Ann Surg 238 : 411 ~ 420
3. [학술지(정기간행물)] - Saad S / 1998 / Portal vein reconstruction in pediatric liver transplantation from living donors / Ann Surg 227 : 275 ~ 281
4. [학술지(정기간행물)] - Cacciarelli TV / 1997 / Factors affecting survival after orthotopic liver transplantation in infants / Transplantation 64 : 242 ~ 248
5. [학술지(정기간행물)] - Millis JM / 1996 / Portal vein thrombosis and stenosis in pediatric liver transplantation / Transplantation 62 : 748 ~ 754
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UCI(KEPA) : I410-ECN-0101-2014-514-001248255