지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.2
- 수록면
- 73 - 80 (8page)
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초록· 키워드
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Purpose: Most recently developed anti-adhesive membranes are not suitable for laparoscopic surgery due to weak mechanical properties or adhesive characteristics. To overcome these problems, we prepared electrospun bioabsorbable nanofibrous poly (lactic-co-glycolic acid)-based membranes as an adhesion barrier. We evaluated the efficacy and safety of this material for laparoscopic surgery in a rabbit model.
Methods: A standardized laparoscopic surgical trauma was made on the rabbit’s uterine horn and adjacent abdominal wall to induce adhesion formation. The injured uterus was covered by a nanofibrous barrier or it was left untreated (the negative control group) (each group: n=14). To evaluate acute toxicity of this material, blood sampling was made 3 and 7 days after laparoscopic surgery to check liver and renal function. Three weeks after laparoscopy, a second look laparoscopy was performed and the adhesions were scored according to Blauer"s scoring system. Tissue between abdominal wall and uterus was obtained to examine microscopically. Liver, kidney and uterus were harvested to examine chronic toxicity.
Results: 36.4% of the nanofiber treatment group and 70% of the untreated control group showed severe adhesions (grade＞3) after laparoscopic surgery but failed to get a statistical significance (P=0.198). Acute and chronic toxicity induced by this material were not noted in the blood and tissue exam.
Conclusion: This study showed that nanofiber barrier seems to be a novel resorbable biomaterial for the reduction of postoperative adhesions. Easy placement and handling of this material make these membranes potentially successful candidates for laparoscopic surgery. But further study is needed to get a statistical significance.
Methods: A standardized laparoscopic surgical trauma was made on the rabbit’s uterine horn and adjacent abdominal wall to induce adhesion formation. The injured uterus was covered by a nanofibrous barrier or it was left untreated (the negative control group) (each group: n=14). To evaluate acute toxicity of this material, blood sampling was made 3 and 7 days after laparoscopic surgery to check liver and renal function. Three weeks after laparoscopy, a second look laparoscopy was performed and the adhesions were scored according to Blauer"s scoring system. Tissue between abdominal wall and uterus was obtained to examine microscopically. Liver, kidney and uterus were harvested to examine chronic toxicity.
Results: 36.4% of the nanofiber treatment group and 70% of the untreated control group showed severe adhesions (grade＞3) after laparoscopic surgery but failed to get a statistical significance (P=0.198). Acute and chronic toxicity induced by this material were not noted in the blood and tissue exam.
Conclusion: This study showed that nanofiber barrier seems to be a novel resorbable biomaterial for the reduction of postoperative adhesions. Easy placement and handling of this material make these membranes potentially successful candidates for laparoscopic surgery. But further study is needed to get a statistical significance.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (18)
참고문헌 신청
1. [학술지(정기간행물)] - Yang HY / 1997 / A clinical analysis of intestinal obstruction in the adult / J Korean Surg Soc 52 : 335 ~ 342
2. [학술지(정기간행물)] - Lee WJ / 1995 / The factors influencing the treatment for the mechanical intestinal obstruction due to adhesion / J Korean Surg Soc 49 : 192 ~ 203
3. [학술지(정기간행물)] - Falk K / 2001 / Reduction of experimental adhesion formation by inhibition of plasminogen activator inhibitor type 1 / Br J Surg 88 : 286 ~ 289
4. [학술지(정기간행물)] - 심희수 / 2002 / 백서에서 수술 후 복부 유착방지용 재료들의 효능평가 / 대한외과학회지 63 (3) : 179 ~ 186
5. [학술지(정기간행물)] - Jansen RP / 1988 / Failure of peritoneal irrigation with heparin during pelvic operations upon young women to reduce adhesions / Surg Gynecol Obstet 166 : 154 ~ 160
2. [학술지(정기간행물)] - Lee WJ / 1995 / The factors influencing the treatment for the mechanical intestinal obstruction due to adhesion / J Korean Surg Soc 49 : 192 ~ 203
3. [학술지(정기간행물)] - Falk K / 2001 / Reduction of experimental adhesion formation by inhibition of plasminogen activator inhibitor type 1 / Br J Surg 88 : 286 ~ 289
4. [학술지(정기간행물)] - 심희수 / 2002 / 백서에서 수술 후 복부 유착방지용 재료들의 효능평가 / 대한외과학회지 63 (3) : 179 ~ 186
5. [학술지(정기간행물)] - Jansen RP / 1988 / Failure of peritoneal irrigation with heparin during pelvic operations upon young women to reduce adhesions / Surg Gynecol Obstet 166 : 154 ~ 160
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UCI(KEPA) : I410-ECN-0101-2013-514-002687969