지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.9
- 수록면
- 161 - 169 (9page)
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Purpose: Long-term exposure to extremely low-frequency (60 ㎐) electromagnetic fields (ELF-EMF) raises the questions of the induction of biological effects including tumorigenesis. One mechanism through which ELF-MFS could influence neoplastic development is the imbalance of cellular proliferation and cell apoptosis. The present study investigated the effect of ELF-EMF on chemically-induced thyroid carcinogenesis in a rat.
Methods: We examined cellular proliferation index measured by anti-Ki-67 antigen, apoptosis, apoptosis related proteins such as caspase 3 and p53, and cell cycle-related proteins (cyclin D1 and p21<SUP>WAF1</SUP>/Cip1). Forty Male F344 rats received a subcutaneous N-bis(2-hydroxypropyl)nitrosamine (DHPN, 2,800 ㎎/㎏) injection, and 1 week later were allowed free access to drinking water containing sulfadimethoxine (0.1%) for 12 weeks. Twenty rats were exposed by ELF-EMF. During the carcinogenesis, sequential histological changes from hyperplasia, adenoma, and ultimately to overt carcinomas were noted.
Results: The exposure group of ELF-EMF, significantly increases the number size of carcinomas. Also, the proliferative and apoptotic indices were significantly increased in the ELF-EMF exposure group than in the control group. The caspase 3 protein expression did not show any significant changes between ELF-EMF group and control group. The p53 protein was not detected in both ELF-EMF exposure and control group. Among the cell cycle related proteins, cyclin D1, not p21<SUP>WAF1</SUP>/Cip1, was significantly increased in adenomas and carcinomas in ELF-EMF exposure group compared with the control group.
Conclusion: Exposure of ELF-EMF effects on chemically-induced rat thyroid carcinogenesis as results of altered increase of cellular proliferation, apoptosis, and cyclin D1 expression.
Methods: We examined cellular proliferation index measured by anti-Ki-67 antigen, apoptosis, apoptosis related proteins such as caspase 3 and p53, and cell cycle-related proteins (cyclin D1 and p21<SUP>WAF1</SUP>/Cip1). Forty Male F344 rats received a subcutaneous N-bis(2-hydroxypropyl)nitrosamine (DHPN, 2,800 ㎎/㎏) injection, and 1 week later were allowed free access to drinking water containing sulfadimethoxine (0.1%) for 12 weeks. Twenty rats were exposed by ELF-EMF. During the carcinogenesis, sequential histological changes from hyperplasia, adenoma, and ultimately to overt carcinomas were noted.
Results: The exposure group of ELF-EMF, significantly increases the number size of carcinomas. Also, the proliferative and apoptotic indices were significantly increased in the ELF-EMF exposure group than in the control group. The caspase 3 protein expression did not show any significant changes between ELF-EMF group and control group. The p53 protein was not detected in both ELF-EMF exposure and control group. Among the cell cycle related proteins, cyclin D1, not p21<SUP>WAF1</SUP>/Cip1, was significantly increased in adenomas and carcinomas in ELF-EMF exposure group compared with the control group.
Conclusion: Exposure of ELF-EMF effects on chemically-induced rat thyroid carcinogenesis as results of altered increase of cellular proliferation, apoptosis, and cyclin D1 expression.
목차
서론
방법
결과
고찰
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Adey WR / 1981 / Tissue interactions with nonionizing electromagnetic fields / Physiol Rev 61 : 435 ~ 514
2. [학술지(정기간행물)] - McCann J / 1998 / The genotoxic potential of electric and magnetic fields: an update / Mutat Res 411 : 45 ~ 86
3. [학술지(정기간행물)] - Minder CE / 2001 / Leukemia, brain tumors, and exposure to extremely low frequency electromagnetic fields in Swiss railway employees / Am J Epidemiol 153 : 825 ~ 835
4. [학술지(정기간행물)] - Cho YH / 2003 / The effect of extremely low frequency electromagnetic fields (ELF-EMF) on the frequency of micronuclei and sister chromatid exchange in human lymphocytes induced by benzo(a)pyrene / Toxicol L 143 : 37 ~ 44
5. [학술지(정기간행물)] - Imai T / 2004 / Sequential analysis of development of invasive thyroid follicular cell carcinomas in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation / Toxicol Pathol 32 : 229 ~ 236
2. [학술지(정기간행물)] - McCann J / 1998 / The genotoxic potential of electric and magnetic fields: an update / Mutat Res 411 : 45 ~ 86
3. [학술지(정기간행물)] - Minder CE / 2001 / Leukemia, brain tumors, and exposure to extremely low frequency electromagnetic fields in Swiss railway employees / Am J Epidemiol 153 : 825 ~ 835
4. [학술지(정기간행물)] - Cho YH / 2003 / The effect of extremely low frequency electromagnetic fields (ELF-EMF) on the frequency of micronuclei and sister chromatid exchange in human lymphocytes induced by benzo(a)pyrene / Toxicol L 143 : 37 ~ 44
5. [학술지(정기간행물)] - Imai T / 2004 / Sequential analysis of development of invasive thyroid follicular cell carcinomas in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation / Toxicol Pathol 32 : 229 ~ 236
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