지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 436 - 441 (6page)
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Purpose: The diagnostic methods for examining suspicious lesions in the breast are becoming less invasive, like core-needle biopsy. Yet, the risk of invasion has been reported to be up to 47% for patients with ductal carcinoma in situ (DCIS) initially diagnosed by core-needle biopsy. The value of sentinel lymph node biopsy (SLNB) for DCIS has not been clearly proved. We searched for the factors associated with invasiveness of preoperatively diagnosed DCIS, and we determined the indications for performing SLNB for patients with preoperatively diagnosed DCIS.
Methods: Between October 1997 and December 2008, we retrospectively reviewed 135 patients with DCIS that was initially diagnosed by core-needle biopsy or other biopsy methods. We compared the invasive breast cancer group, which was finally diagnosed with the pure DCIS group in regards to clinical, radiological, and pathological factors.
Results: 21.5% of the patients with initial diagnosis of DCIS were finally diagnosed with invasive breast cancer. On univariate analysis, the statistically meaningful factors for invasiveness were palpable lesion (P＜0.0001), core-needle diagnosis (P=0.007), large tumor size (P=0.028), high nuclear grade (P=0.002), and negative estrogen receptor (P=0.005). On multivariate analysis, a palpable lesion was the only independent risk factor (odds ratio 3.9 (1.1 to 13.8); P=0.035). Axillar lymph node metastases were found in three patients in the invasive cancer group. There was no lymph node metastasis in the DCIS group.
Conclusion: We recommend that SLNB be considered in initially diagnosed DCIS with palpable lesion or high nuclear grade due to the high risk of invasiveness.
Methods: Between October 1997 and December 2008, we retrospectively reviewed 135 patients with DCIS that was initially diagnosed by core-needle biopsy or other biopsy methods. We compared the invasive breast cancer group, which was finally diagnosed with the pure DCIS group in regards to clinical, radiological, and pathological factors.
Results: 21.5% of the patients with initial diagnosis of DCIS were finally diagnosed with invasive breast cancer. On univariate analysis, the statistically meaningful factors for invasiveness were palpable lesion (P＜0.0001), core-needle diagnosis (P=0.007), large tumor size (P=0.028), high nuclear grade (P=0.002), and negative estrogen receptor (P=0.005). On multivariate analysis, a palpable lesion was the only independent risk factor (odds ratio 3.9 (1.1 to 13.8); P=0.035). Axillar lymph node metastases were found in three patients in the invasive cancer group. There was no lymph node metastasis in the DCIS group.
Conclusion: We recommend that SLNB be considered in initially diagnosed DCIS with palpable lesion or high nuclear grade due to the high risk of invasiveness.
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결과
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결론
REFERENCES
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - The Consensus Conference Committee / 1997 / Consensus Conference on the classification of ductal carcinoma in situ / Cancer 80 : 1798 ~ 1802
2. [학술지(정기간행물)] - Schwartz GF / 2000 / Consensus conference on the treatment of in situ ductal carcinoma of the breast, April 22-25, 1999 / Cancer 88 : 946 ~ 954
3. [학술지(정기간행물)] - Mokbel K / 2003 / Towards optimal management of ductal carcinoma in situ of the breast / Eur J Surg Oncol 29 : 191 ~ 197
4. [학술지(정기간행물)] - Anderson BO / 2000 / Axillary metastases with DCIS: is the glass half empty or half full? / Ann Surg Oncol 7 : 631 ~ 633
5. [학술지(정기간행물)] - Meijnen P / 2005 / Changing patterns in diagnosis and treatment of ductal carcinoma in situ of the breast / Eur J Surg Oncol 31 : 833 ~ 839
2. [학술지(정기간행물)] - Schwartz GF / 2000 / Consensus conference on the treatment of in situ ductal carcinoma of the breast, April 22-25, 1999 / Cancer 88 : 946 ~ 954
3. [학술지(정기간행물)] - Mokbel K / 2003 / Towards optimal management of ductal carcinoma in situ of the breast / Eur J Surg Oncol 29 : 191 ~ 197
4. [학술지(정기간행물)] - Anderson BO / 2000 / Axillary metastases with DCIS: is the glass half empty or half full? / Ann Surg Oncol 7 : 631 ~ 633
5. [학술지(정기간행물)] - Meijnen P / 2005 / Changing patterns in diagnosis and treatment of ductal carcinoma in situ of the breast / Eur J Surg Oncol 31 : 833 ~ 839
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