지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 428 - 435 (8page)
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초록· 키워드
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Purpose: Immunosuppressive regimen based on reduced-dose Tacrolimus (TAC) is widely accepted in the field of renal transplantation. However, optimal targetsfor TAC whole blood trough concentrations during the early period after kidney transplantation remain uncertain.
Methods: A total of 184 consecutive adult renal transplant recipients with triple immunosuppression (TAC/Mycophenolate/corticosteroid) were included in this study. According to the trough level of TAC at day 7 after transplantation, patients were classified as low TAC concentration (LT, ＜10 ng/㎖, n=85), intermediate TAC concentration (IT, 10∼15 ng/㎖, n=75), and high TAC concentration (HT, ＞15 ng/㎖, n=24) groups. Rate of acute rejection, graft function and side effects of TAC within 1 yr after transplantation were evaluated.
Results: There was no difference in trough concentrations of TAC at 2 weeks, 1 month, 3 months, 6 months and 12 months after transplantation among the three groups. Significantly higher incidence of acute rejection within 2 weeks after transplantation was observed in LT group compared with IT and HT groups (17.4%, 5.6% and 4.8%, respectively, P=0.037). HT patients showed significantly better estimated glomerular filtration rates until 6 months after transplantation than IT and LT patients (75.5±24.8 vs. 63.8±12.8 and 64.3±15.2 ㎖/min at 6 months, P=0.03). There was no significant difference in TAC toxicity in terms of post-transplant diabetes and renal toxicity.
Conclusion: Short-term high TAC exposure immediately after kidney transplantation may provide lower incidence of acute rejection and better restoration of graft function compared with low or intermediate TAC exposure.
Methods: A total of 184 consecutive adult renal transplant recipients with triple immunosuppression (TAC/Mycophenolate/corticosteroid) were included in this study. According to the trough level of TAC at day 7 after transplantation, patients were classified as low TAC concentration (LT, ＜10 ng/㎖, n=85), intermediate TAC concentration (IT, 10∼15 ng/㎖, n=75), and high TAC concentration (HT, ＞15 ng/㎖, n=24) groups. Rate of acute rejection, graft function and side effects of TAC within 1 yr after transplantation were evaluated.
Results: There was no difference in trough concentrations of TAC at 2 weeks, 1 month, 3 months, 6 months and 12 months after transplantation among the three groups. Significantly higher incidence of acute rejection within 2 weeks after transplantation was observed in LT group compared with IT and HT groups (17.4%, 5.6% and 4.8%, respectively, P=0.037). HT patients showed significantly better estimated glomerular filtration rates until 6 months after transplantation than IT and LT patients (75.5±24.8 vs. 63.8±12.8 and 64.3±15.2 ㎖/min at 6 months, P=0.03). There was no significant difference in TAC toxicity in terms of post-transplant diabetes and renal toxicity.
Conclusion: Short-term high TAC exposure immediately after kidney transplantation may provide lower incidence of acute rejection and better restoration of graft function compared with low or intermediate TAC exposure.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Meier-Kriesche HU / 2006 / Immunosuppression: evolution in practice and trends, 1994-2004 / Am J Transplant 6 : 1111 ~ 1131
2. [학술지(정기간행물)] - Webster AC / 2005 / Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data / BMJ 331 : 810 ~
3. [학술지(정기간행물)] - Opelz G / 2009 / Influence of immunosuppressive regimens on graft survival and secondary outcomes after kidney transplantation / Transplantation 87 : 795 ~ 802
4. [학술지(정기간행물)] - Samaniego M / 2006 / Drug insight: maintenance immunosuppression in kidney transplant recipients / Nat Clin Pract Nephrol 2 : 688 ~ 699
5. [학술지(정기간행물)] - Ihara H / 1995 / Intra- and interindividual variation in the pharmacokinetics of tacrolimus (FK506) in kidney transplant recipients--importance of trough level as a practical indicator / Int J Urol 2 : 151 ~ 155
2. [학술지(정기간행물)] - Webster AC / 2005 / Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data / BMJ 331 : 810 ~
3. [학술지(정기간행물)] - Opelz G / 2009 / Influence of immunosuppressive regimens on graft survival and secondary outcomes after kidney transplantation / Transplantation 87 : 795 ~ 802
4. [학술지(정기간행물)] - Samaniego M / 2006 / Drug insight: maintenance immunosuppression in kidney transplant recipients / Nat Clin Pract Nephrol 2 : 688 ~ 699
5. [학술지(정기간행물)] - Ihara H / 1995 / Intra- and interindividual variation in the pharmacokinetics of tacrolimus (FK506) in kidney transplant recipients--importance of trough level as a practical indicator / Int J Urol 2 : 151 ~ 155
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