지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.6
- 수록면
- 69 - 78 (10page)
이용수
이 논문의 연구 히스토리 (5)
2008
Effect of Phytic Acid on the Formation of Colonic Aberrant Crypt Foci induced by azoxymethane in Fe-deficient ICR Mice
Jin-Joo Hue
,
Ji-Yeon Han
,
Ki-Nam Lee
외 7명
Laboratory Animal Research
2008.12
학술저널
Protective effect of phytic acid on the formation of aberrant crypt foci induced by azoxymethane in the colon of male ICR mice
Jin-Joo Hue
,
Ki-Nam Lee
,
Myak Miga
외 5명
한국실험동물학회 학술발표대회 논문집
2008.11
학술대회자료
Protective effect of phytic acid on the formation of aberrant crypt foci induced by azoxymethane in the colon of male ICR mice
Jin-Joo Hue
,
Ki-Nam Lee
,
Bong Su Kang
외 4명
Journal of Biomedical Research
2008.06
학술저널
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
A level of dietary iron may play a role in colon carcinogenesis. The effect of dietary iron on colon carcinogenesis was investigated in male ICR mice. Five-week old mice were acclimated for one week and fed on iron-normal diet (35 ppm Fe), iron-deficient diet (3 ppm), or iron-overloaded diet (350 ppm Fe) for 8 weeks. Animals received three (0-2<SUP>nd</SUP> weeks after starting experiment) injections of azoxymethane (AOM; 10mg/kg b.w.) to induce colonic aberrant crypt foci (ACF). There were five experimental groups including normal control without AOM, AOM+iron-normal diet (AOM+NFe), AOM+iron-deficient (AOM+LFe), AOM+ironoverloaded diet (AOM+HFe) groups. The total numbers of ACF and aberrant crypt (AC) were measured in the colonic mucosa after staining with methylene blue. The blood and serum were analyzed with a blood cell differential counter and an automatic serum analyzer. The hepatic iron levels were significantly dependent on the presence of iron in the diets. Iron-deficient diet significantly decreased the several hematological values. The values of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvate transaminase (GPT) were also significantly decreased in iron-overloaded or iron-deficient diet groups, compared with normal iron diet group. Dietary iron-deficiency decreased the numbers of ACF (64.9) and AC (79.8) per colon by 20.6 and 21.8%, respectively, compared with AOM+NFe group (72.4 ACF/colon and 90.3 AC/colon). However, ironoverloaded diet increased ACF (82.9) and AC (96.0) induction by AOM, compared with normal iron diet. These results suggest that dietary iron can affect the colon carcinogenesis in the animal model of mice.
목차
ABSTRACT
Introduction
Materials and Methods
Results
Discussion
Acknowledgements
References
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UCI(KEPA) : I410-ECN-0101-2013-528-002902890