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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 37 - 45 (9page)
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이 논문의 연구 히스토리 (5)
2008
Effect of Phytic Acid on the Formation of Colonic Aberrant Crypt Foci induced by azoxymethane in Fe-deficient ICR Mice
Jin-Joo Hue
,
Ji-Yeon Han
,
Ki-Nam Lee
외 7명
Laboratory Animal Research
2008.12
학술저널
Protective effect of phytic acid on the formation of aberrant crypt foci induced by azoxymethane in the colon of male ICR mice
Jin-Joo Hue
,
Ki-Nam Lee
,
Myak Miga
외 5명
한국실험동물학회 학술발표대회 논문집
2008.11
학술대회자료
Protective effect of phytic acid on the formation of aberrant crypt foci induced by azoxymethane in the colon of male ICR mice
Jin-Joo Hue
,
Ki-Nam Lee
,
Bong Su Kang
외 4명
Journal of Biomedical Research
2008.06
학술저널
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초록· 키워드
오류제보하기
Phytic acid (PA) is a naturallu occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plants and mammalian cells. Recently PA has received much attention for its role in anticancer activity. We investigated the preventive effect of PA on the formation of colonic aberrant crypt foci (ACF), a preneoplastic lesion, induced by azoxymethane (AOM). After acclimation for one week, six-week old male ICR mice were fed on the AIN-93G purified diet and PA (0.5% or 2% PA in water) for 8 weeks. The animals were treated with azoxymethane (AOM, 10 mg/kg b.w.) three times (0, 1, and 2 weeks) to induce colonic aberrant crypt foci (ACF). After sacrifice, the total numbers of aberrant crypts (AC) and ACF in colonic mucosa were counted after staining with methylene blue. Blood and serum were analyzed with a blood cell differential counter and an automatic serum analyzer. AOM treatment without PA induced the total numbers of 85.7 ± 12.9 and 115.2 ± 19.9, respectively. PA at the dose of 2% AC/colon by PA at the dose of 0.5% were 73.4 ± 12.9 and 115.2 ± 19.9, respectively. PA at the dose of 2% significantly decreased the ACF and AC numbers to 56.5 ± 14.6 and 95.4 ± 17.2, respectively (p＜0.01). PA at the doses of 0.5 and 2% decreased the numbers of ACF and AC/colon in a dose-dependent manner. Although some parameters in blood counts and serum chemistry were changed compared with the control, no specific toxicity was found. Theses findings suggest that phytic acid can be a chemopreventive agent for colon carcinogenesis resulting from inhibition of the development of ACF in ICR mice.
목차
ABSTRACT
Introduction
Materials and Methods
Results
Discussion
Acknowledgements
References
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