지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 40 - 46 (7page)
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초록· 키워드
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Ginseng, the root of Panax ginseng Meyer, has been used frequently in traditional oriental medicine and is popular globally. Ginsenosides, which are the saponins in ginseng, are the major components having pharmacological and biological activities, including anti-diabetic and anti-tumor activities. In this study, we investigated the effects of total saponin from Korean red ginseng (TSKRG) on thrombin-produced thromboxane A₂ (TXA₂), an aggregating thrombogenic molecule, and its associated microsomal enzymes cyclooxygenase (COX)-1 and TXA₂ synthase (TXAS). Thrombin (0.5 U/mL) increased TXA₂ production up to 169 ng/10? platelets as compared with control (0.2 ng/10? platelets). However, TSKRG inhibited potently TXA₂ production to the control level in a dose-dependent manner, which was associated with the strong inhibition of COX-1 and TXAS activities in platelet microsomes having cytochrome c reductase activity. The results demonstrate TSKRG is a benefi cial traditional oriental medicine in platelet-mediated thrombotic diseases via suppression of COX-1 and TXAS to inhibit production of TXA₂.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (38)
참고문헌 신청
Schwartz SM / 1990 / Developmental mechanisms underlying pathology of arteries / Physiol Rev 70:1177~1209
Berridge MJ / 1984 / Inositol trisphosphate, a novel second messenger in cellular signal transduction / Nature 312:315~321
Jennings LK. / 2009 / Role of platelets in at4Aherothrombosis / Am J Cardiol 103:4A~10A
Pasqui AL / 1991 / Nitroprusside in vitro inhibits platelet aggregation and intracellular calcium translocation. Effect of haemoglobin / Thromb Res 61:113~122
Nishikawa M / 1980 / Ca2+-calmodulindependent phosphorylation and platelet secretion / Nature 287:863~865
Berridge MJ / 1984 / Inositol trisphosphate, a novel second messenger in cellular signal transduction / Nature 312:315~321
Jennings LK. / 2009 / Role of platelets in at4Aherothrombosis / Am J Cardiol 103:4A~10A
Pasqui AL / 1991 / Nitroprusside in vitro inhibits platelet aggregation and intracellular calcium translocation. Effect of haemoglobin / Thromb Res 61:113~122
Nishikawa M / 1980 / Ca2+-calmodulindependent phosphorylation and platelet secretion / Nature 287:863~865
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UCI(KEPA) : I410-ECN-0101-2013-524-001261123