지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 273 - 281 (9page)
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초록· 키워드
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Our previous study demonstrated that the Korean traditional medicine Gyeongshingangjeehwan (GGEx) inhibits obesity and insulin resistance in obese type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. We investigated whether GGEx may affect AMP-activated protein kinase α (AMPKα) since AMPKα activation is known to stimulate fatty acid oxidation in skeletal muscle of obese rodents. After OLETF rats were treated with GGEx, we studied the effects of GGEx on AMPKα and acetyl-CoA carboxylase (ACC) phosphorylation, and the expression of AMPKα, PPARα, and PPARα target genes. The effects of GGEx on mRNA expression of the above genes were also measured in C2C12 skeletal muscle cells. Administration of GGEx to OLETF rats for 8 weeks increased phosphorylation of AMPKα and ACC in skeletal muscle. GGEx also elevated skeletal muscle mRNA levels of AMPKα1 and AMPKα2 as well as PPARα and its target genes. Consistent with the in vivo data, similar activation of genes was observed in GGEx-treated C2C12 cells. These results suggest that GGEx stimulates skeletal muscle AMPKα and PPARα activation, leading to alleviation of obesity and related disorders.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
Acknowledgements
REFERENCES
참고문헌 (24)
참고문헌 신청
Acín A / 1999 / Cloning and characterization of the 5' flanking region of the human uncoupling protein 3 (UCP3) gene / Biochem Biophys Res Commun 258:278~283
Bandyopadhyay GK / 2006 / Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects / Diabetes 55:2277~2285
Brun S / 1999 / Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth / Diabetes 48:1217~1222
Carling D / 2004 / The AMP-activated protein kinase cascade--a unifying system for energy control / Trends Biochem Sci 29:18~24
Collier CA / 2006 / Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle / Am J Physiol Regul Integr Comp Physiol 291:182~189
Bandyopadhyay GK / 2006 / Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects / Diabetes 55:2277~2285
Brun S / 1999 / Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth / Diabetes 48:1217~1222
Carling D / 2004 / The AMP-activated protein kinase cascade--a unifying system for energy control / Trends Biochem Sci 29:18~24
Collier CA / 2006 / Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle / Am J Physiol Regul Integr Comp Physiol 291:182~189
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UCI(KEPA) : I410-ECN-0101-2013-326-001453838