지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Although there are many potential cytotoxic molecules released from bacteria, the role of these molecules on the apoptosis of various cancer cells is not well understood. Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative, aerobic and rod-shaped bacterium, and has a number of virulence factors. To understand the cytotoxic effect of bacterial extracts on the colorectal cancer cell line, HCT 116 cells, we examined alteration of the cell viability, proliferation, cell cycle and apoptosis of HCT 116 cells after treatment with extract of P. aeruginosa (PaE). These cytotoxicity of PaE occurred in a time- and a dose-dependent manners. In addition, PaE arrested the cell cycle of HCT 116 cell in a timedependent manner. PaE inhibited the protein levels of Bcl-2 and induced the release of cytochrome c from mitochondria of HCT 116 cells. The decrease of procaspase-3 was induced by the treatment of PaE. These results indicate that PaE has a cytotoxicity in HCT 116 cells via the induction of apoptosis associated with mitochondrial pathway. Therefore, PaE may used as the potential target for the treatment of colorectal cancer.
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REFERENCES
참고문헌 (22)
참고문헌 신청
Adams KW / 2007 / Rapid turnover of mcl-1 couples translation to cell survival and apoptosis / J Biol Chem 282:6192~6200
Andersson Y / 2004 / Downregulation of the antiapoptotic MCL-1 protein and apoptosis in MA-11 breast cancer cells induced by an anti-epidermal growth factor receptor-Pseudomonas exotoxin A immunotoxin / Int J Cancer 112:475~483
Bender CM / 1998 / Inhibition of DNA methylation by 5-Aza-2'- deoxycytidine suppresses the growth of human tumor cell lines / Cancer Research 58:95~101
Brattain MG / 1981 / Heterogeneity of malignant cells from a human colonic carcinoma / Cancer Research 41:1751~1756
Chakrabarty AM / 2003 / Microorganisms and Cancer: Quest for a therapy / J Bacteriol 185:2683~2686
Andersson Y / 2004 / Downregulation of the antiapoptotic MCL-1 protein and apoptosis in MA-11 breast cancer cells induced by an anti-epidermal growth factor receptor-Pseudomonas exotoxin A immunotoxin / Int J Cancer 112:475~483
Bender CM / 1998 / Inhibition of DNA methylation by 5-Aza-2'- deoxycytidine suppresses the growth of human tumor cell lines / Cancer Research 58:95~101
Brattain MG / 1981 / Heterogeneity of malignant cells from a human colonic carcinoma / Cancer Research 41:1751~1756
Chakrabarty AM / 2003 / Microorganisms and Cancer: Quest for a therapy / J Bacteriol 185:2683~2686
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UCI(KEPA) : I410-ECN-0101-2013-510-001743920