지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.2
- 수록면
- 38 - 45 (8page)
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초록· 키워드
오류제보하기
Antioxidant and anti-rheumatoid activities of Cirsium japonicum leaf extract (CJLE) were investigated in this study. CJLE had similar DPPH radical scavenging activity and reducing power to ascorbic acid and several flavonoids. Rheumatoid arthritis (RA) is a chronic inflammatory tissue-destructive disease, partly related with functions of hyaluronidases (HAases) and collgenases. CJLE (1,000 μg/mL) had approximately 60.7 and 31.9% inhibition of HAase and collagenase activity, respectively. Also, CJLE inhibited lipopolysaccharide (LPS)-induced nitrite production in a dose-dependent manner, and CJLE (1,000 μg/mL) suppressed approximately 70% of LPS-induced nitrite production effectively in RAW 264.7 macrophage cells. CJLE had inhibitory effects on the adherence of monocytic THP-1 to human umbilical vein endothelial cell (HUVEC) monolayers to the basal level. Inhibitory effect of CJLE on the adhesion was caused by suppression of tumor necrosis factor-a-upregulated expression of vascular cellular adhesion molecule-1 (VCAM-1) and E-selectin. We expect that CJLE may alleviate the inflammatory process in rheumatoid synovium, and these findings will raise the possibility of the usage of C. japonicum as a traditional pharmaceutical of anti-rheumatoid arthritis.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (67)
참고문헌 신청
Lui S , 2006 , She L, Yang Z. Tumor inhibition and improve immunity in mice treated with flavone from Cirsium japonicum DC , Int. Immunopharmacol 6 : 1387 ~ 1393
Grzycka K , 1987 , Research on the biological activity if selected species of flower plant , Ann. Univ. Mariae Curie Sklodowska 33 : 275 ~ 283
Nazaruk J , 2005 , Flavonoid composition and antimicrobial activity of Cirsium rivulare (Jacq.) All. flowers , J. Ethnopharmacol 102 : 208 ~ 212
Lee HK , 2003 , Antioxidant, antimutagenicity, and anticancer activities of extracts from Cirsium japonicum var. ussurense KITAMURA , Korean J. Med. Crop Sci 11 : 53 ~ 61
이성현 , 2006 , 부위별 고려엉겅퀴(Cirsium setidens Nakai)의이화학적 성상 및 항산화 활성 효과 , 한국식품과학회지 38 (4) : 571 ~ 576
Grzycka K , 1987 , Research on the biological activity if selected species of flower plant , Ann. Univ. Mariae Curie Sklodowska 33 : 275 ~ 283
Nazaruk J , 2005 , Flavonoid composition and antimicrobial activity of Cirsium rivulare (Jacq.) All. flowers , J. Ethnopharmacol 102 : 208 ~ 212
Lee HK , 2003 , Antioxidant, antimutagenicity, and anticancer activities of extracts from Cirsium japonicum var. ussurense KITAMURA , Korean J. Med. Crop Sci 11 : 53 ~ 61
이성현 , 2006 , 부위별 고려엉겅퀴(Cirsium setidens Nakai)의이화학적 성상 및 항산화 활성 효과 , 한국식품과학회지 38 (4) : 571 ~ 576
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UCI(KEPA) : I410-ECN-0101-2013-573-001009911