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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 235 - 244 (10page)
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초록· 키워드
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In this study, aloe fermentation products were derived from mycelia from 3 mushrooms: Ganoderma lucidum (AG), Hericium erinaceum (AH), and Phellinus linteus (AP). Levels of aloin A and B increased with fermentation time. The highest levels were measured on the fifth day of fermentation. β-Glucan levels decreased with fermentation time. The safety of aloe fermentation products were examined in male and female Sprague-Dawley rats. Rats were orally administered the three aloe fermentation products at dose levels of 1, 2 or 5 g/kg for single-dose toxicity test and 0.5, 1, or 2 g/kg for repeated-dose toxicity test. There were no significant differences in body weight gain between vehicle control and AG-, AH- or AP-treated rats. Also, significant changes in daily feed intake and water consumption were not observed. In hematological analysis, none of the parameters were affected by aloe fermentation products with mushroom mycelia. This suggests that there are no negative effects on homeostasis and immunity. In blood biochemistry analysis, none of the markers were affected by feeding rats with AG, AH or AP. Similarly, there were no significant effects on markers for liver, kidney, skeletal and heart muscle functions. No remarkable lesions were observed in these organs at histopathology. Since there were no adverse effects of AG, AH and AP in single- or repeated-dose toxicity tests, even at higher doses than normal, we conclude that the aloe fermentation products with mushroom mycelia possess long-term safety and could be candidates as multifunctional nutrients for the improvement of intestinal function and immunity.
목차
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (26)
참고문헌 신청
조영제 / 2006 / Phosphatidic acid로 유도된 Raw cell에서 알로에 베라 및알로에 센스의 염증 억제 효과 / Journal of the Korean Society for Applied Biological Chemistry 49(1):65~69
Kang MH / 2005 / Antigastritic and antiulcerative effect of Pulmuone Healthy Aloe Gel / Korean J Pharm Soc 49(3):237~243
Hong HS / 1999 / The Comparative of inhibitory effect of various solvent extracts from Aloe arborescens and Aloe vera on tumor cell lines using clonoginic assay / Korean J Pharmacogn 30(3):275~279
Lee YW / 1996 / Effects of Aloe vera on the cholesterol and vitamin D2-induced atherosclerosis in rats / J Fd Hyg Safety 11(4):243~259
Woo N / 1995 / Antioxidative Effect of Aloe (Aloe arborescences) Extracts on Linoleic Acid and Soybean Oil / Korean J Soc Food Sci 11(5):536~541
Kang MH / 2005 / Antigastritic and antiulcerative effect of Pulmuone Healthy Aloe Gel / Korean J Pharm Soc 49(3):237~243
Hong HS / 1999 / The Comparative of inhibitory effect of various solvent extracts from Aloe arborescens and Aloe vera on tumor cell lines using clonoginic assay / Korean J Pharmacogn 30(3):275~279
Lee YW / 1996 / Effects of Aloe vera on the cholesterol and vitamin D2-induced atherosclerosis in rats / J Fd Hyg Safety 11(4):243~259
Woo N / 1995 / Antioxidative Effect of Aloe (Aloe arborescences) Extracts on Linoleic Acid and Soybean Oil / Korean J Soc Food Sci 11(5):536~541
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UCI(KEPA) : I410-ECN-0101-2013-510-000764470