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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.9
- 수록면
- 249 - 256 (8page)
이용수
이 논문의 연구 히스토리 (4)
2008
In vivo antioxidant effects of ginseng intestinal metabolite (IH901) in endurance exercise-induced oxidative stress rat model
Nam-Jin Lee
,
Yu-Ri Jung
,
Chun Mei Lin
외 2명
한국실험동물학회 학술발표대회 논문집
2008.11
학술대회자료
In vitro antioxidant properties of ginseng intestinal metabolite (IH901)
Nam-Jin Lee
,
Yu-Ri Jung
,
Chun Mei Lin
외 2명
한국실험동물학회 학술발표대회 논문집
2008.11
학술대회자료
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
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초록· 키워드
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This study was conducted to investigate whether administration of IH901, a ginseng intestinal metabolite, ameliorates exercise-induced oxidative stress while preserving antioxidant defense capability in rat skeletal muscles and lung. Eight adult male Sprague-Dawley rats per group were randomly assigned to the resting control, exercise control, resting with IH901 (25, 50, and 100 mg/kg) consumption (R/IH901), or exercise with IH901 (25, 50, and 100 mg/kg) consumption (E/IH901) group. The trained groups ran 35 min 2 days/week for 8 weeks. To analyze the IH901-training interaction, serum biochemical analysis, lipid peroxidation, citrate synthase, protein oxidation, antioxidant and superoxide dismutase in skeletal muscles and lung tissue were measured. Compared to the exercise control group, animals that consumed IH901 had significantly increased exercise endurance times (p ＜ 0.05) and decreased plasma creatine kinase and lactate dehydrogenase levels (p ＜ 0.05), while those in the E/IH901 groups had increased citrate synthase and anti-oxidant enzymes and decreased lipid peroxidation and protein oxidation (p ＜ 0.05). In conclusion, IH901 consumption in aging rats after eccentric exercise has beneficial effects on anti-inflammatory and anti-oxidant activities through down-regulation of pro-inflammatory mediators, lipid peroxidation, and protein oxidation and up-regulation of anti-oxidant enzymes.
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