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논문 기본 정보

자료유형
학술저널
저자정보
Ji-Yeon Hwang (인제대학교) Soo-Kyung Lee (인제대학교) Ja-Rim Jo (인제대학교) Mi-Eun Kim (인제대학교) Hyun-Ah So (동아대학교) Chang-Woo Cho (동아대학교) Young-Wan Seo (한국해양대학교) Jung-In Kim (인제대학교)
저널정보
한국영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.1 No.4
발행연도
2007.12
수록면
371 - 375 (5page)

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To control blood glucose level as close to normal is a major goal of treatment of diabetes mellitus. Hyperglycemia and hyperlipidemia are the major risk factors for cardiovascular complications, the major cause of immature death among the patients with type 2 diabetes. The purpose of this study is to determine the hypoglycemic and hypolipidemic effects of Salicornia herbacea in animal model of type 2 diabetes and to investigate the possible mechanisms for the beneficial effects of S. herbacea. S. herbacea was extracted with 70% ethanol and desalted with 100% ethanol. Three week-old db/db mice (C57BL/KsJ, n=16) were fed AIN-93G semipurified diet or diet containing 1% desalted ethanol extract of S. herbacea for 6 weeks after 1 week of adaptation. Fasting plasma glucose, triglyceride, and total cholesterol were measured by enzymatic methods and blood glycated hemoglobin (HbA<SUB>1C</SUB>) by the chromatographic method. Body weight and food intake of S. herbacea group were not significantly different from those of the control group. Fasting plasma glucose and blood glycated hemoglobin levels tended to be lowered by S. herbacea treatment. Consumption of S. herbacea extract significantly decreased plasma triglyceride and cholesterol levels (p<0.05). The inhibition of S. herbacea extract against yeast α-glucosidase was 31.9% of that of acarbose at the concentration of 0.5 ㎎/mL in vitro. The inhibitory activity of ethanol extract of S. herbacea against porcine pancreatic lipase was 59.0% of that of orlistat at the concentration of 0.25 ㎎/mL in vitro. Thus, these results suggest that S. herbacea could be effective in controlling hyperlipidemia by inhibition of pancreatic lipase in animal model of type 2 diabetes.

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Abstract
Introduction
Materials and Methods
Results
Discussion
Literature Cited

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UCI(KEPA) : I410-ECN-0101-2013-594-000330712