지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 104 - 111 (8page)
이용수
초록· 키워드
오류제보하기
Objectives : Delirium is a disorder that needs active treatments since it is associated with poor outcomes such as comorbidity, longer hospital stay, higher mortality rate, higher rates of institutional care and dementia. This study was done to investigate the efficacy and safety of amisulpride, a atypical antipsychotic drug that is in possession of distinguishable pharmacodynamic profile characteristics from other widely used atypical antipsychotic drugs, but it has characteristics that are most similar to haloperidol which was the most commonly used antipsychotic drug treating patients with delirium in a safe manner.
Methods : We recruited 19 delirium patients. Korean version of Delirium Rating Scale-Revised-98(K-DRS-R-98) and Korean version of Delirium Rating Scale(K-DRS) had been used to measure severity and improvement of delirium symptoms. Clinical Global Impression Severity Score(CGI-S) had been used to examine general medical conditions in the patients. The assessment on side effects began from day 2 for every visit to patients using Simpson-Angus Scale(SAS), Barnes Akathisia Rating Scale(BARS), Abnormal Involuntary Movement Scale(AIMS).
Results : A total of 14 patients completed the study. They were administered with mean amisulpride dose 86.16 (SD=39.01) ㎎ per day. The K-DRS scores were decreased from 21.57±4.72 before the treatment to 7.14±0.84 after the treatment(p＜0.01). The K-DRS-R-98 scores also were significantly decreased from 25.07±6.40 before the treatment to 9.93±1.09 after the treatment(p＜0.01). Among detailed K-DRS-R-98 scale items, the sleep item also showed a significant decrease(p＜0.01). There was no patient who suffered serious side effects. In 35.7% of the patients, the mild rigidity and mild tremor of extrapyramidal symptoms occurred.
Conclusion : Amisulpride is expected to be used effectively and safely in treating delirium patients.
Methods : We recruited 19 delirium patients. Korean version of Delirium Rating Scale-Revised-98(K-DRS-R-98) and Korean version of Delirium Rating Scale(K-DRS) had been used to measure severity and improvement of delirium symptoms. Clinical Global Impression Severity Score(CGI-S) had been used to examine general medical conditions in the patients. The assessment on side effects began from day 2 for every visit to patients using Simpson-Angus Scale(SAS), Barnes Akathisia Rating Scale(BARS), Abnormal Involuntary Movement Scale(AIMS).
Results : A total of 14 patients completed the study. They were administered with mean amisulpride dose 86.16 (SD=39.01) ㎎ per day. The K-DRS scores were decreased from 21.57±4.72 before the treatment to 7.14±0.84 after the treatment(p＜0.01). The K-DRS-R-98 scores also were significantly decreased from 25.07±6.40 before the treatment to 9.93±1.09 after the treatment(p＜0.01). Among detailed K-DRS-R-98 scale items, the sleep item also showed a significant decrease(p＜0.01). There was no patient who suffered serious side effects. In 35.7% of the patients, the mild rigidity and mild tremor of extrapyramidal symptoms occurred.
Conclusion : Amisulpride is expected to be used effectively and safely in treating delirium patients.
목차
서론
연구대상 및 방법
결과
고찰
결론
참고문헌
참고문헌 (62)
참고문헌 신청
1. [단행본] - / 1994 / American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders(DSM-IV) 4th edition / American Psychiatric Association
2. [학술지(정기간행물)] - Trzepacz PT / 1999 / Practice guideline for the treatment of patients with delirium / Am J Psychiatry 156 : 1 ~ 20
3. [학술지(정기간행물)] - Lipowski ZJ / 1987 / Delirium(acute confusional states) / JAMA 258 : 1789 ~ 1792
4. [학술지(정기간행물)] - Young J / 2007 / Delirium in older people / BMJ 334 : 842 ~ 846
5. [학술지(정기간행물)] - Siddiqi N / 2006 / Occurrence and outcome of delirium in medical in-patients:a systematic literature review / Age Ageing 35 : 350 ~ 364
2. [학술지(정기간행물)] - Trzepacz PT / 1999 / Practice guideline for the treatment of patients with delirium / Am J Psychiatry 156 : 1 ~ 20
3. [학술지(정기간행물)] - Lipowski ZJ / 1987 / Delirium(acute confusional states) / JAMA 258 : 1789 ~ 1792
4. [학술지(정기간행물)] - Young J / 2007 / Delirium in older people / BMJ 334 : 842 ~ 846
5. [학술지(정기간행물)] - Siddiqi N / 2006 / Occurrence and outcome of delirium in medical in-patients:a systematic literature review / Age Ageing 35 : 350 ~ 364
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UCI(KEPA) : I410-ECN-0101-2013-513-000478070