지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 95 - 102 (8page)
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초록· 키워드
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The effect of DHU001, a mixed herbal formula consisted of 7 types aqueous extracts for various respiratory disorders were evaluated on the formalin-induced paw chronic inflammation in mice after oral administration. Mice were subaponeurotically injected in the left hind paw with 0.02 ㎖ of 3.75% formalin, then subjected to 500, 250 and 125 ㎎/㎏ of DHU001 oral administration, once a day for 10 days during which then the hind-paw thickness and volume were measured daily. The paw wet-weight, histological profiles, histomorphometrical analyses and paw tumor necrosis factor (TNF)-α contents were conducted at termination. After two formalin treatments, a marked increase in the paw thickness and volume was detected in the formalin-injected control as compared with that in the intact control, plus at the time of sacrifice the paw wet-weights, paw TNF-α contents were also dramatically increased with severe chronic inflammation signs at histopathological observations. However, these formalin-induced chronic inflammatory changes were dramatically decreased by treatment of dexamethasone and all three different dosages of DHU001. DHU001 has favorable effects on formalin-induced chronic inflammation mediated by TNF-α suppression, and DHU001 may represent an alternative approach for the treatment of chronic inflammatory diseases.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENT
REFERENCES
참고문헌 (22)
참고문헌 신청
Aimbire, F. / 2007 / Effect of hydroalcoholicextract of Zingiber officinalis rhizomes on LPS-induced rat airwayhyperreactivity and lung inflammation. ProstaglandinsLeukot / Essent. Fatty Acids 77:129~138
Akindele, A.J / 2007 / Antiinflammatoryactivity of the aqueous leaf extract of Byrsocarpus coccineus / Fitoterapia 78:25~28
Amin, A.R. / 1995 / The mode of actionof aspirin-like drugs: effect on inducible nitric oxide synthase / Proc. Natl. Acad. Sci 92:7926~7930
Young-Doo Back / 2008 / Effects of DHU001, a Mixed Herbal Formula on Acute Inflammation in Mice / 한국독성학회지 24(3):189~194
Bianchi, M. / 2004 / Increased substance P and tumor necrosis factor-alphalevel in the paws following formalin injection in rat tail / BrainRes 1019:255~258
Akindele, A.J / 2007 / Antiinflammatoryactivity of the aqueous leaf extract of Byrsocarpus coccineus / Fitoterapia 78:25~28
Amin, A.R. / 1995 / The mode of actionof aspirin-like drugs: effect on inducible nitric oxide synthase / Proc. Natl. Acad. Sci 92:7926~7930
Young-Doo Back / 2008 / Effects of DHU001, a Mixed Herbal Formula on Acute Inflammation in Mice / 한국독성학회지 24(3):189~194
Bianchi, M. / 2004 / Increased substance P and tumor necrosis factor-alphalevel in the paws following formalin injection in rat tail / BrainRes 1019:255~258
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UCI(KEPA) : I410-ECN-0101-2013-513-000636810