The purpose of this study was to investigate the the changes in several clinical parameters after fruit diet and combined exercise according to haptoglobin protein polymorphism of obese female university students. A total of 16 obese female university students were recruited, and started fruit diet and exercise, but only 9 participants complete this program. The haptoglobin protein polymorphism was determined by Peacock's polyacrylaminde gel electrophoresis method, and blood iron parameters analyzed by automatic analyzer. The fruit diet and combined exercise program for 7 days indicated the significant reduction in obesity associated parameters including weight, BMI, fat mass and %body fat(p<.05). When the changes in serum iron parameters after this program according to haptoglobin polymorphism were analyzed, the changes in total iron binding capacity(TIBC) value were observed in the participants with Hp11 + Hp21 phenotypes, suggesting the significant reduction of TIBC value in this group(p<.05). These data suggest that haptoglobin protein polymorphism may be one of genetic predisposition showing the inter-individual differences of several clinical parameters on fruit diet and combined exercise program. for 7 days.