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We evaluated the immunomodulatory effects of proanthocyanidin-rich extract (PAE) from Pinus radiata bark in broiler. Proliferation of peripheral blood mononuclear cells and thymocytes was significantly enhanced in 2.5, 5, 10 ㎎/㎏ PAE-treated broiler chickens. Proliferation of splenocytes was significantly enhanced in 1.25, 2.5, 5, 10 ㎎/㎏ PAE-treated broiler chickens. These effects were markedly enhanced by the presence of LPS, which acts on B cells responsible for humoral immunity, and Con A, which acts directly on T cells involved in cell mediated immunity. PAE significantly promoted the expression of interleukin-18 and interleukin-1β. Thus, PAE from P. radiata possesses immunomodulatory effects in broiler chickens.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENTS
LITERATURE CITED
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Bagchi D / 2000 / Free radical and grape seed proanthocyanidin extract: Importance in human health and disease prevention / Toxicology 148 : 187 ~ 197
2. [학술지(정기간행물)] - Buttke TM / 1993 / Use of an aqueous soluble tetrazolium/formazan assay to measure viability and proliferation of lymphokine-dependent cell lines / J Immunol Methods 157 : 233 ~ 240
3. [학술지(정기간행물)] - Dinarello CA / 1998 / Overview of interleukin-18: more than an interferon-g inducing factor / J Leukoc Biol 63 : 658 ~ 664
4. [학술지(정기간행물)] - Gupta, A / 2006 / Immunomodulatory activity of biopolymeric fraction RLJ-NE-205 from Picrorhiza kurroa / Int Immunopharmacol 6 : 1543 ~ 1549
5. [학술지(정기간행물)] - Hunter CA / 1997 / Comparison of the effects of interleukin-1α, interleukin-1β and interferon-γ-inducing factor on the production of interferon-δ by natural killer / Eur J Immunol 27 : 2787 ~ 2792
2. [학술지(정기간행물)] - Buttke TM / 1993 / Use of an aqueous soluble tetrazolium/formazan assay to measure viability and proliferation of lymphokine-dependent cell lines / J Immunol Methods 157 : 233 ~ 240
3. [학술지(정기간행물)] - Dinarello CA / 1998 / Overview of interleukin-18: more than an interferon-g inducing factor / J Leukoc Biol 63 : 658 ~ 664
4. [학술지(정기간행물)] - Gupta, A / 2006 / Immunomodulatory activity of biopolymeric fraction RLJ-NE-205 from Picrorhiza kurroa / Int Immunopharmacol 6 : 1543 ~ 1549
5. [학술지(정기간행물)] - Hunter CA / 1997 / Comparison of the effects of interleukin-1α, interleukin-1β and interferon-γ-inducing factor on the production of interferon-δ by natural killer / Eur J Immunol 27 : 2787 ~ 2792
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Immunomodulatory effect of a proanthocyanidin-rich extract from Pinus radiata bark by dosing period in chickens
한국가금학회 정기총회 및 학술발표회
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Characterization of Low Molecular Weight Polyphenols from Pine(Pinus radiata) Bark
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UCI(KEPA) : I410-ECN-0101-2012-527-004154619