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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 345 - 351 (7page)
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초록· 키워드
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Brain damage resulting from perinatal cerebral hypoxia and ischemia is a major cause of acute mortality and neurological disabilities, including cerebral palsy (CP) and cognitive dysfunction. In order to establish an experimental hypoxia-ischemia (HI) model of CP for the screening of therapeutics, we operated bilateral common carotid artery ligation (BCAO) and monolateral carotid artery occlusion (MCAO), followed by 15 min of hypoxia (8% oxygen) in 4-day-old rats, and evaluated neurobehavioral disorders. After surgery, the survival rates of male and female BCAO rats were 33.3 and 7.1%, respectively, whereas 100% and 82.4% MCAO rats survived. In neurobehavioral performances, both male and female BCAO rats showed delayed achievement of righting reflex, in contrast to a negligible effect in MACO animals. However, both BCAO and MCAO rats exhibited impairment of cliff avoidance performances, although the physical dysfunction was more severe in BCAO than in MCAO. In global locomotor activity, MCAO rats also displayed decreased fast-moving time comparable BCAO animals, and increased resting and slowmoving times. In addition, MCAO rats showed marked learning and memory deficit in passive avoidance performances, similar to BCAO animals. From immunostaining analyses, severe degradation and loss of myelin basic proteins were observed in the brain of BCAO rats, in contrast to a mild aggregation in MCAO animals. Therefore, it is suggested that MCAO should be a more suitable CP model than BCAO, based on the high survival rate, relatively-mild brain injury, and enough neurobehavioral disorders for the research on preventive and therapeutic compounds.
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재료 및 방법
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고찰
감사의 글
참고문헌
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - Altman, J. / 1971 / The influence of nutrition on neural and behavioral development. 3. Development of some motor, particularly locomotor patterns during infancy / Dev. Psychobiol. 4 : 97 ~ 114
2. [학술지(정기간행물)] - Altman, J. / 1975 / Postnatal development of locomotion in the laboratory rat / Anim. Behav. 23 : 896 ~ 920
3. [학술지(정기간행물)] - Archer, L.N.J. / 1986 / Cerebral artery doppler ultrasonography for prediction of outcome after perinatal asphyxia / Lancet 2 : 1116 ~ 1118
4. [학술지(정기간행물)] - Back, S.A. / 2002 / Selective vulnerability of late oligodendrocyte progenitors to hypoxiaischemia / J. Neurosci. 22 : 455 ~ 463
5. [학술지(정기간행물)] - Back, S.A. / 2001 / Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury / J. Neurosci. 21 : 1302 ~ 1312
2. [학술지(정기간행물)] - Altman, J. / 1975 / Postnatal development of locomotion in the laboratory rat / Anim. Behav. 23 : 896 ~ 920
3. [학술지(정기간행물)] - Archer, L.N.J. / 1986 / Cerebral artery doppler ultrasonography for prediction of outcome after perinatal asphyxia / Lancet 2 : 1116 ~ 1118
4. [학술지(정기간행물)] - Back, S.A. / 2002 / Selective vulnerability of late oligodendrocyte progenitors to hypoxiaischemia / J. Neurosci. 22 : 455 ~ 463
5. [학술지(정기간행물)] - Back, S.A. / 2001 / Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury / J. Neurosci. 21 : 1302 ~ 1312
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UCI(KEPA) : I410-ECN-0101-2012-510-003862922