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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 323 - 330 (8page)
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초록· 키워드
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Ovarian cancer is the most lethal cause of death from gynecological malignancies in the Western world. Over 90% of human ovarian cancers arise in the ovarian surface epithelium (OSE). The OSE surrounding the ovary is simple mesothelium and squamous to flat-cubobidal mesothelial cells. This cell type of ovary has both epithelial and mesenchymal potential. Also OSE cells are regulated by many factors such as cytokines, growth factors, and multiple hormones. Nevertheless OSE function is poorly understood. In particular, ovarian cancers are closely related with hereditary predisposition. Hereditary ovarian tumors are commonly associated with mutations in tumor suppressor genes such as brca1 and brca2 genes. These genes play a role in maintenance of genome integrity, DNA repair, cell cycle control and apoptosis. Mutations in brca1 and/or brca2 may lead to carcinogenesis through distinct molecular pathways like estrogen-mediated proliferation, the presence of a p53 mutation, and the modulation of the activity of NF-kB. Especially the dysfunction of brca1 triggers the inactivation of p53 and a higher proportion of a p53 mutation is commonly linked to brca-linked ovarian tumorigenesis. The dysfunction of brca1 and/or brca2 can arise from multiple mechanisms in the regulation of both JNK and ERK1/2 signaling. For more effective diagnosis and therapy of ovarian cancer, the role of brca1 and/or brca2 in ovarian cancer has to be distinctively elucidated by the animal models in which the gene functions are deleted in mouse OSE cells and by the mechanisms by which these genes affect ovarian carcinogenesis.
목차
Ovarian surface epithelium
Epithelial ovarian cancer
Gene mutations in epithelial ovarian tumors
In vivo models of epithelial ovarian cancer
Brca1 and brca2 as tumor suppressor genes
Brca1 and brca2 in ovarian cancer
Summary
Acknowledgments
References
참고문헌 (98)
참고문헌 신청
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Auersperg, N. / 1998 / The biology of ovarian cancer / Semin. Oncol. 25:281~304
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Alberg, A.J. / 1997 / Epidemiology, prevention, and early detection of breast cancer / Curr. Opin. Oncol. 9:505~511
Auersperg, N. / 2003 / Specific keynote: experimental models of epithelial ovarian carcinogenesis / Gynecol. Oncol. 88:S47~S54
Auersperg, N. / 1998 / The biology of ovarian cancer / Semin. Oncol. 25:281~304
Auersperg, N. / 1995 / Expression of two mucin antigens in cultured human ovarian surface epithelium: influence of a family history of ovarian cancer / Am. J. Obstet. Gynecol. 173:558~565
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UCI(KEPA) : I410-ECN-0101-2012-510-003862891