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자료유형
학술저널
저자정보
Young-Su Yang (안전성평가연구소) Jinsoo Lee (안전성평가연구소) Soonjin Kwon (안전성평가연구소) Heung-Sik Seo (안전성평가연구소) Seong-Jin Choi (안전성평가연구소) Hee-Jin Yu (안전성평가연구소) Jeong-Ah Song (안전성평가연구소) Kyuhong Lee (안전성평가연구소) Byoung-Seok Lee (안전성평가연구소) Jeong-Doo Heo (안전성평가연구소) Kyu-Hyuk Cho (안전성평가연구소) Chang-Woo Song (안전성평가연구소)
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.26 No.4
발행연도
2010.12
수록면
293 - 300 (8page)

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tert-Butyl acetate (TBAc) is an organic solvent, which is commonly used in architectural coatings and industrial solvents. It has recently been exempted from the definition of a volatile organic compound (VOC) by the Air Resources Board (ARB). Since the use of TBAc as a substitute for other VOCs has increased, thus its potential risk in humans has also increased. However, its inhalation toxicity data in the literature are very limited. Hence, inhalation exposure to TBAc was carried out to investigate its toxic effects in this study. Adult male rats were exposed to TBAc for 4 h for 1 day by using a nose-only inhalation exposure chamber (low dose, 2370 ㎎/㎥ (500 ppm); high dose, 9482 ㎎/㎥ (2000 ppm)). Sham-treated control rats were exposed to clean air in the inhalation chamber for the same period. The animals were killed at 2, 7, and 15 days after exposure. At each time point, body weight measurement, bronchoalveolar lavage fluid (BALF) analysis, histopathological examination, and biochemical assay were performed. No treatment-related abnormal effects were observed in any group according to time course. Based on those findings, the median lethal concentration (LC??) of TBAc was over 9482 ㎎/㎥ in this study. According to the MSDS, the 4 h LC?? for TBAc for rats is over 2230 ㎎/㎥. We suggested that this value is changed and these findings may be applied in the risk assessment of TBAc which could be beneficial in a sub-acute study.

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES

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UCI(KEPA) : I410-ECN-0101-2012-513-003909836