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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.9
- 수록면
- 241 - 247 (7page)
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The present study was carried out to provide a guideline for injecting tribromoethanol (TBE) as the main anesthetic agent, while adjusting the doses of xylazine (X) and medetomidine (M) according to different strains of mice (male ICR, C57BL/6, and BALB/c). Seven intraperitoneal injection anesthesia protocols using TBE and mixtures of TBE and α₂?adrenergic agonists (TBE/X and TBE/M) were compared in terms of their efficacy and safety (anesthetic duration, death rate, and the development of pathological lesions of abdominal organs). All animals that were injected with a low dose of TBE (200 ㎎/㎏) displayed clear signs of light anesthesia with a strong pedal withdrawal reflex. Despite the good anesthetic effect, a high dose of TBE (400 ㎎/㎏) was not a suitable anesthetic for major surgery in all mouse strains because of the risk of pathologic changes in the abdominal organs, such as retention of the digestive tract, peritonitis, and fibrinoid adhesion. TBE200/X10 and TBE200/M0.5 (TBE, 200 ㎎/㎏; X, 10 ㎎/㎏; M, 0.5 ㎎/㎏) appeared to be safe and provided satisfactory anesthesia in ICR mice. Finally, there were clear differences in anesthetic efficacy among ICR, C57BL/6, and BALB/c strains. TBE/M and TBE/X did not anesthetize BALB/c mice, and it anesthetized C57BL/6 mice for a short time. When administered with TBE/X and TBE/M maintained the sedation of ICR mice. We were able to establish different regimes for each strain (TBE200/X20 for C57BL/6, TBE300/X10 and TBE200/M1 for BALB/c). Our results showed that TBE/X and TBE/M could be recommended as an anesthetic mixture, with the dose appropriately adjusted according to mouse strain.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Arras, M. / 2001 / Optimization of intraperitoneal injection anesthesia in mice: Drugs, dosages, adverse effects, and anesthesia depth / Comp. Med. 51 (5) : 443 ~ 456
2. [학술지(정기간행물)] - Bette, M. / 2004 / Influence of different anaesthetics on pro-inflammatory cytokine expression in rat spleen / Lab. Anim. 38 (3) : 272 ~ 279
3. [학술지(정기간행물)] - Buitrago, S. / 2008 / Safety and efficacy of various combinations of injectable anesthetics in BALB/c mice / J. Am. Assoc. Lab. Anim. Sci. 47 (1) : 11 ~ 17
4. [학술지(정기간행물)] - Coria-Avila, G.A. / 2007 / Cecum location in rats and the implications for intraperitoneal injections / Lab. Anim. 36 (7) : 25 ~ 30
5. [단행본] - Fish, R.E. / 2008 / Pharmacology of injectable anesthetics, sedatives, and tranquilizers in Anesthesia and Analgesia in Laboratory Animals / Academic Press : 27 ~ 82
2. [학술지(정기간행물)] - Bette, M. / 2004 / Influence of different anaesthetics on pro-inflammatory cytokine expression in rat spleen / Lab. Anim. 38 (3) : 272 ~ 279
3. [학술지(정기간행물)] - Buitrago, S. / 2008 / Safety and efficacy of various combinations of injectable anesthetics in BALB/c mice / J. Am. Assoc. Lab. Anim. Sci. 47 (1) : 11 ~ 17
4. [학술지(정기간행물)] - Coria-Avila, G.A. / 2007 / Cecum location in rats and the implications for intraperitoneal injections / Lab. Anim. 36 (7) : 25 ~ 30
5. [단행본] - Fish, R.E. / 2008 / Pharmacology of injectable anesthetics, sedatives, and tranquilizers in Anesthesia and Analgesia in Laboratory Animals / Academic Press : 27 ~ 82
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UCI(KEPA) : I410-ECN-0101-2012-510-003686428