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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.3
- 수록면
- 69 - 74 (6page)
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이 논문의 연구 히스토리 (3)
2010
Proteomic Identification of Proteins Differentially Expressed by Melatonin in Hepatic Ischemia-Reperfusion Injury
Eun-Hae Cho
,
Jin-Hee Sung
,
Myeong-Ok Kim
외 4명
한국실험동물학회 학술발표대회 논문집
2010.08
학술대회자료
Proteomic Analysis of Hepatic Ischemia and Reperfusion Injury in Mice
Eun-Hae Cho
,
Jin-Hee Sung
,
Phil-Ok Koh
Laboratory Animal Research
2010.03
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Hepatic ischemia/reperfusion (I/R) injury is an inevitable consequence during liver surgery. I/R injury induces serious hepatic dysfunction and failure. In this study, we identified proteins that were differentially expressed between sham and I/R injured livers. Animals were subjected to hepatic ischemia for 1 hr and were sacrificed at 3hr after reperfusion. Serum ALT and AST levels were significantly increased in I/R-operated animals compared to those of sham-operated animals. Ischemic hepatic lobes of I/R-operated animals showed the hepatic lesion with unclear condensation and sinusoidal congestion. Proteins from hepatic tissue were separated using two dimensional gel electrophosresis. Protein spots with a greater than 2.5-fold change in intensity were identified by mass spectrometry. Among these proteins, glutaredoxin-3, peroxiredoxin-3, glyoxalase I, spermidine synthase, dynamin-1-like protein, annexin A4, eukaryotic initiation factor 3, eukaryotic initiation factor 4A-I, 26S proteasome, proteasome alpha 1, and proteasome beta 4 levels were significantly decreased in I/R-operated animals compared to those of sham-operated animals. These proteins are related to protein synthesis, cellular growth and stabilization, anti-oxidant action. Moreover, Western blot analysis confirmed that dynamin-1-like protein levels were decreased in I/R-operated animals. Our results suggest that hepatic I/R induces the hepatic cells damage by regulation of several proteins.
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UCI(KEPA) : I410-ECN-0101-2010-510-003342694