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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.9
- 수록면
- 319 - 324 (6page)
이용수
이 논문의 연구 히스토리 (3)
2010
Proteomic Identification of Proteins Differentially Expressed by Melatonin in Hepatic Ischemia-Reperfusion Injury
Eun-Hae Cho
,
Jin-Hee Sung
,
Myeong-Ok Kim
외 4명
한국실험동물학회 학술발표대회 논문집
2010.08
학술대회자료
Proteomic Analysis of Hepatic Ischemia and Reperfusion Injury in Mice
Eun-Hae Cho
,
Jin-Hee Sung
,
Phil-Ok Koh
Laboratory Animal Research
2010.03
학술저널
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초록· 키워드
오류제보하기
It is known that estrogen protects tissues against organ ischemia. This study examined the protective effect of estrogen against hepatic ischemia and reperfusion. Rats were subjected to hepatic ischemia for 60 min and were sacrificed at 3, 6, 12, 24 hr after reperfusion. Estrogen (4 ㎎/㎏) or oil was administered at 1 hr before hepatic ischemia. Alanine aminotransferase and asparatate aminotransferase levels were immediately increased after reperfusion, peaked at 6 hr and then declined gradually. Alanine aminotransferase and asparatate aminotransferase levels were significantly suppressed by estrogen treatment. After 24 hr of reperfusion, ischemic lobe showed inflammatory lesions with severe congestion in oil-treated group. However, in estrogen-treated group, only mild congestion was observed. In histological observation, severity of hepatic injury was getting worse in process of time. In oil-treated animals, most ischemic liver lobes showed hepatocyte necrosis and massive neutrophils infiltration. However, estrogen attenuated the damage of hepatic tissue caused by hepatic ischemic and reperfusion injury. Thus, our results suggest that estrogen play a potent protective role against hepatic injury.
목차
서론
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Boland, R. / 2008 / 17beta-Estradiol signaling in skeletal muscle cells and its relationship to apoptosis / Steroids 73 : 859 ~ 863
2. [학술지(정기간행물)] - Burkhardt, M. / 2008 / The effect of estrogen on hepatic microcirculation after ischemia/reperfusion / Int. J. Colorectal Dis 23 : 113 ~ 119
3. [학술지(정기간행물)] - Crosby, K.M. / 2007 / Estrogen limits ischemic cell death by modulating caspase-12-mediated apoptotic pathways following middle cerebral artery occlusion / Neuroscience 146 : 1524 ~ 1535
4. [학술지(정기간행물)] - Eckhoff, D.E. / 2002 / 17-Beta-estradiol protects the liver against warm ischemia/reperfusion injury and is associated with increased serum nitric oxide and decreased tumor necrosis factor-alpha / Surgery 132 : 302 ~ 309
5. [학술지(정기간행물)] - Eum, H.A. / 2007 / Necrosis and apoptosis: sequence of liver damage following reperfusion after 60 min ischemia in rats / Biochem. Biophys. Res. Commun 358 : 500 ~ 505
2. [학술지(정기간행물)] - Burkhardt, M. / 2008 / The effect of estrogen on hepatic microcirculation after ischemia/reperfusion / Int. J. Colorectal Dis 23 : 113 ~ 119
3. [학술지(정기간행물)] - Crosby, K.M. / 2007 / Estrogen limits ischemic cell death by modulating caspase-12-mediated apoptotic pathways following middle cerebral artery occlusion / Neuroscience 146 : 1524 ~ 1535
4. [학술지(정기간행물)] - Eckhoff, D.E. / 2002 / 17-Beta-estradiol protects the liver against warm ischemia/reperfusion injury and is associated with increased serum nitric oxide and decreased tumor necrosis factor-alpha / Surgery 132 : 302 ~ 309
5. [학술지(정기간행물)] - Eum, H.A. / 2007 / Necrosis and apoptosis: sequence of liver damage following reperfusion after 60 min ischemia in rats / Biochem. Biophys. Res. Commun 358 : 500 ~ 505
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