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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 407 - 411 (5page)
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초록· 키워드
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Peroxiredoxin-2 (Prx-2), an isoform of the antioxidant enzyme family, has been exerts neuroprotective effects against oxidative stress. Estradiol exerts neuroprotective effects against a various stimuli including excitotoxic amino acids and oxidative stress. This study investigated whether estradiol regulates Prx-2 expression in middle cerebral artery occlusion (MCAO)-induced injury and glutamate exposure-induced neuronal cell death. Adult female rats were ovariectomized and treated with oil or estradiol prior to MCAO. Brains were collected at 24 hr after MCAO and the cerebral cortices were isolated. Proteomic analysis and Western blot analysis demonstrated that MCAO induces a decrease in Prx-2, and pretreatment with estradiol prevents MCAO-induced decrease in Prx-2. Moreover, glutamate exposure induced a decrease in Prx-2 in a hippocampal-derived cell lines, and pretreatment with estradiol prevented the glutamate toxicity-induced decrease in Prx-2. This study suggests that estradiol exerts neuroprotective effects during neuronal cell damage by modulating of Prx-2.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Behl, C. / 1995 / 17β-Estradiol protects neurons from oxidative stress-induced cell death in vitro / Biochem. Biophys. Res. Commun 216 (2) : 473 ~ 482
2. [학술지(정기간행물)] - Boulos, S. / 2007 / Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury / J. Neurosci. Res 85 (14) : 3089 ~ 3097
3. [학술지(정기간행물)] - Chae, H.Z. / 1994 / Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes / Proc. Natl. Acad. Sci. U. S. A. 91 (15) : 7017 ~ 7021
4. [학술지(정기간행물)] - Culmsee, C. / 1999 / Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: evidence for a receptor-independent antioxidative mechanism / J. Cereb. Blood Flow. Metab 19 (11) : 1263 ~ 1269
5. [학술지(정기간행물)] - Dubal, D. B. / 1998 / Estradiol protects against ischemic injury / J. Cereb. Blood Flow Metab 18 (11) : 1253 ~ 1258
2. [학술지(정기간행물)] - Boulos, S. / 2007 / Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury / J. Neurosci. Res 85 (14) : 3089 ~ 3097
3. [학술지(정기간행물)] - Chae, H.Z. / 1994 / Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes / Proc. Natl. Acad. Sci. U. S. A. 91 (15) : 7017 ~ 7021
4. [학술지(정기간행물)] - Culmsee, C. / 1999 / Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: evidence for a receptor-independent antioxidative mechanism / J. Cereb. Blood Flow. Metab 19 (11) : 1263 ~ 1269
5. [학술지(정기간행물)] - Dubal, D. B. / 1998 / Estradiol protects against ischemic injury / J. Cereb. Blood Flow Metab 18 (11) : 1253 ~ 1258
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Expression of peroxiredoxin I regulated by gonadotropins in the rat ovary
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UCI(KEPA) : I410-ECN-0101-2010-510-001694159