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자료유형
학술저널
저자정보
저널정보
한국실험동물학회 Laboratory Animal Research Laboratory Animal Research Vol.25 No.3
발행연도
2009.9
수록면
207 - 212 (6page)

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초록· 키워드

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A novel composition of ginsenosides with high Rd and Rg3 content, UG0712 was evaluated for exercise capacity, and post-exercise fatigue recovery through in vivo treadmill maximum running test (MRT) under continuous training (n=9) or resting (n=10) conditions of the SD rats. The standardized ginseng root extract (UG0714) was used for efficacy comparison. Each animal was treated orally at the dose of 25 ㎎/ ㎏ for 8 weeks in exercise group or 9 weeks in resting group. Blood lactate dehydrogenase (LDH) activity and lactic acid concentration were measured to evaluate the post-exercise fatigue recovering effect after exhausted exercise. MRT of UG0712 group showed statistically significant 27.8% increase at week two (P<0.05) and maintained at an increased level in 8-weeks (27.6% increase, not significance) compared with vehicle treated control group. In resting group, MRT of UG0712 after 8-weeks treatment showed 23.0% increase compared with vehicle group (P<0.05) and 23.5% increase when compared with UG0714 group (P<0.05). While no significant changes were found in UG0714 group under either exercise or resting conditions. UG0712 group showed significantly decreased blood LDH levels compared with both vehicle (P<0.01) and UG0714 (P<0.05) groups under trained condition but no significant changes in resting condition. In addition, UG0712 significantly decreased blood lactic acid levels in trained (P<0.01) group, while UG0714 showed no significant changes. Considering the evaluation results from both exercise capability and post-exercise fatigue recovery status, it can be concluded that administration of a standardized Rd and Rg3 ginsenoside composition, UG0712 improves endurance exercise performance probably via increased aerobic energy metabolism, and accelerated post-exercise fatigue recovery.

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Materials and Methods
Results
Discussion
Acknowledgment
References

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