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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.9
- 수록면
- 104 - 111 (8page)
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초록· 키워드
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Although ginseng (genus Panax) leaf extract contains high concentrations of bioactive constituents, its effects have been reported in few preclinical studies, and information regarding its toxicity is not sufficient to allow for its clinical use. We evaluated the genotoxicity of UG0712, which is a powdered extract of ginseng leaves. UG0712 did not increase the number of revertant colonies in 4 histidine auxotrophic strains of Salmonella typhimurium (TA100, TA1535, TA98, and TA1537) or in a tryptophan auxotrophic strain of Escherichia coli (WP2uvrA(pKM101)) at any concentration evaluated, either in the absence or presence of the metabolic activation system. There was no significant increase in the number of metaphase cells with structural or numerical aberrations in the UG0712-treated groups compared to the concurrent vehicle control at any dose, regardless of the presence of the metabolic activation system. Oral administration of the extract at doses up to 2,000 mg/kg in male mice did not increase the frequency of micronucleated polychromatic erythrocytes in the bone marrow, and did not result in any significant clinical signs, body weight loss, gross findings, or mortality. These results suggest that UG0712 does not act as a mutagenic or genotoxic material at the concentrations evaluated.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Attele AS. / 1999 / Ginseng pharmacology : multiple constituents and multiple actions / Biochem Pharmacol 58 (11) : 1685 ~ 1693
2. [학술지(정기간행물)] - Cheng Y. / 2005 / Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action / Acta Pharmacol Sin 26 (2) : 143 ~ 149
3. [학술지(정기간행물)] - Shin HR. / 2000 / The cancerpreventive potential of Panax ginseng : a review of human and experimental evidence / Cancer Causes Control 11 (6) : 565 ~ 576
4. [학술지(정기간행물)] - Wang H. / 2009 / Ginseng leaf-stem : bioactive constituents and pharmacological functions / Chin Med 4 : 20 ~
5. [학술지(정기간행물)] - Cheng TO. / 2000 / Panax(ginseng)is not a panacea / Arch Intern Med 160 (21) : 3329 ~
2. [학술지(정기간행물)] - Cheng Y. / 2005 / Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action / Acta Pharmacol Sin 26 (2) : 143 ~ 149
3. [학술지(정기간행물)] - Shin HR. / 2000 / The cancerpreventive potential of Panax ginseng : a review of human and experimental evidence / Cancer Causes Control 11 (6) : 565 ~ 576
4. [학술지(정기간행물)] - Wang H. / 2009 / Ginseng leaf-stem : bioactive constituents and pharmacological functions / Chin Med 4 : 20 ~
5. [학술지(정기간행물)] - Cheng TO. / 2000 / Panax(ginseng)is not a panacea / Arch Intern Med 160 (21) : 3329 ~
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UCI(KEPA) : I410-ECN-0101-2015-500-002710852