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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.3
- 수록면
- 41 - 46 (6page)
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The oncogene c-Fos involved in cell cycle progression is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes such as activator protein-1 (AP-1). In various cancers including squamous cell carcinoma, hepatocellular carcinoma and osteosarcoma, c-Fos expression may be relevant to the carcinogenic events. In the present study, the expression patterns and the potential importance of c-Fos in cholangiocarcinogenesis were evaluated by immunohistochemical staining for c-Fos in the selected each five cases of precancerous lesion (interim stage of cholangiocarcinogenesis, 8 weeks after liver fluke infection) and cholangiocarcinoma (ChC) derived from the hamster ChC model. Additionally, c-Fos immunoreactivity of 5 cases of carcinogen-unaffected hyperplastic bile ducts obtained from 12-day bile duct ligation model was also evaluated. Nuclear expression of c-Fos was apparent in most of the cell components of dysplastic bile ducts and cholangiocarcinoma. However, normal and well-organized hyperplastic bile ducts (type 1 hyperplastic bile ducts) were almost negative. These expression patterns were positively correlated with those of proliferating cell nuclear antigen (PCNA), suggesting that c-Fos overexpression might be associated with the high cellular proliferating activity and cell transformation in the hamster cholangiocarcinogenesis.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Bakin, A.V. / 1999 / Role of DNA 5-methylcytosine transferase in cell transformation by Fos / Science 283 : 387 ~ 390
2. [학술지(정기간행물)] - Bamberger, A.M. / 2001 / Expression pattern of the AP-1 family in endometrial cancer: correlation with cell cycle regulations / J. Cancer Res. Clin. Oncol 127 : 545 ~ 550
3. [학술지(정기간행물)] - Feng, D.Y. / 2001 / Effect of phosphorylation of MAPK and Stat3 and expression of c-Fos and c-Jun proteins on hepatocarcinogenesis and their clinical significance / World J. Gastroenterol 7 : 33 ~ 36
4. [학술지(정기간행물)] - Franchi, A. / 1998 / Immunhistochemical detection of c-Fos and c-Jun expression in osseous and cartilaginous tumours of the skeleton / Virchows Arch 432 : 515 ~ 519
5. [학술지(정기간행물)] - Fujimoto, J. / 1995 / Clinical implication of Fos and Jun expressions and protein kinase activity in endometrial cancers / Eur. J. Gynaecol. Oncol 16 : 138 ~ 146
2. [학술지(정기간행물)] - Bamberger, A.M. / 2001 / Expression pattern of the AP-1 family in endometrial cancer: correlation with cell cycle regulations / J. Cancer Res. Clin. Oncol 127 : 545 ~ 550
3. [학술지(정기간행물)] - Feng, D.Y. / 2001 / Effect of phosphorylation of MAPK and Stat3 and expression of c-Fos and c-Jun proteins on hepatocarcinogenesis and their clinical significance / World J. Gastroenterol 7 : 33 ~ 36
4. [학술지(정기간행물)] - Franchi, A. / 1998 / Immunhistochemical detection of c-Fos and c-Jun expression in osseous and cartilaginous tumours of the skeleton / Virchows Arch 432 : 515 ~ 519
5. [학술지(정기간행물)] - Fujimoto, J. / 1995 / Clinical implication of Fos and Jun expressions and protein kinase activity in endometrial cancers / Eur. J. Gynaecol. Oncol 16 : 138 ~ 146
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UCI(KEPA) : I410-ECN-0101-2009-510-019510629